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EPIMECH

Financiado

Shaping intestine epithelium using viscoelastically dynamic matrices

Intestine epithelium (IE) compartmentalization and morphogenesis are profoundly influenced by intrinsic biochemical signals and microenvironmental cues in the extracellular matrix (ECM), especially viscoelasticity. Recent studies... ver más

31/12/2026

CNRS

212K€

Presupuesto del proyecto: 212K€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-05-14

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

I+D

Cerrada hace 1 año

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2 Participantes

CNRS

211.75K€ | Lider

UPCité

N.D. | Participante

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25-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 52 concesiones

25-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 1 concesiones

25-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 6 concesiones

Duración del proyecto: 31 meses Fecha Inicio: 2024-05-14
Fecha Fin: 2026-12-31

Presupuesto del proyecto 212K€

Descripción del proyecto Intestine epithelium (IE) compartmentalization and morphogenesis are profoundly influenced by intrinsic biochemical signals and microenvironmental cues in the extracellular matrix (ECM), especially viscoelasticity. Recent studies have revealed substrate mechanical properties have clear influences on intestine stem cell (ISC) fate, IE polarity, self-organization and morphogenesis. However, most of these investigations were performed in constant and static conditions, neglecting the active and dynamic nature of in vivo ECM. Furthermore, whether and how dynamic matrix viscoelasticity contributes to the emergence of symmetry breaking and tissue regionalization in early intestinal morphogenesis remains elusive so far. In this project, we propose to use dynamic hydrogel-based matrices with light-triggerable changes in viscoelasticity to study the transduction of molecular mechanosensing into collective cell dynamics during symmetry breaking and tissue patterning in IE development. We hypothesize that anisotropic substrate viscoelasticity could heterogeneously activate mechanosensing pathways in ISCs and affect ISC proliferation and differentiation, leading to changes in cell activities, sorting and tissue segregation. In brief, with dynamic substrates, we will create viscoelastic patterns/gradients by in situ light patterning and elucidate IE dynamics related to the emergence of cell shape, migration, ISC fate and tissue compartmentalization as functions of the mechanical stimuli. We also aim to identify the molecular principles of IE mechanotransduction, which will improve our understanding of IE development, morphogenesis and homeostasis. The know-how from this project will also enable the fabrication of artificial intestine-on-a-chip devices for further developmental studies. Relying on the multidiscipline approaches, this action will greatly enhance the competence of the researcher as well as bring added value in scientific and societal aspects for the EU.

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