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GLUCOCLOCK

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Role of the nuclear receptor Rev erbalpha in lipid and glucose homeostasis and t...

Role of the nuclear receptor Rev erbalpha in lipid and glucose homeostasis and the transduction of circadian signals into metabolic responses The increasing incidence of obesity and type 2 diabetes is becoming a major health problem in the European Community and has a considerable economic and social cost. There is therefore an urgent need to understand the basics of th... ver más

31/08/2013

INSERM

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2013-08-31 No tenemos la información de la convocatoria

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1 Participantes

INSERM

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Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The increasing incidence of obesity and type 2 diabetes is becoming a major health problem in the European Community and has a considerable economic and social cost. There is therefore an urgent need to understand the basics of these diseases. Physiological processes are subjected to natural daily fluctuations. Interestingly, daily cycles in insulin secretion and glucose tolerance are lost in patients with type 2 diabetes. There is an increased incidence of obesity, metabolic syndrome and cardiovascular disease among shift-workers. These observations pinpoint to a causal relationship between rhythm disturbances and metabolic disorders. Genes of the clock machinery directly influence energy homeostasis as exemplified by Clock mutant mice which are hyperphagic, become obese and diabetic. Metabolic pathways are tightly controlled nuclear receptors. For instance Rev-erbalpha is involved in lipid metabolism, bile acid synthesis and adipogenesis. Interestingly, Rev-erbalpha is also a clock and clock-controlled gene. Therefore Rev-erbalpha may coordinate metabolic processes and peripheral circadian outputs. The objectives of this proposal are: 1. To assess the role of Rev-erbalpha in lipid and glucose homeostasis and the development of insulin resistance and type 2 diabetes. 2. To determine whether Rev-erbalpha plays a role in the intricate link between peripheral circadian molecular clocks and metabolic pathways. This project will provide molecular basis to explain the interaction between circadian rhythms and lipid and glucose metabolism and may therefore suggest possibilities for new therapeutic approaches that take circadian rhythms into account. A long term possibility is the development of more finely tuned, and hopefully more optimal, treatments of dyslipidemia, insulin resistance and type 2 diabetes.

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