Innovating Works

CUL7 AND DIABETES

Financiado
Role of the Cullin7 E3 ubiquitin ligase in insulin signaling and diabetes
This grant application is formulated to explore the biological role of the Cullin7 (CUL7) E3 ubiquitin ligase in insulin signaling and its implication for diabetes. My previous work led to the identification of insulin receptor su... This grant application is formulated to explore the biological role of the Cullin7 (CUL7) E3 ubiquitin ligase in insulin signaling and its implication for diabetes. My previous work led to the identification of insulin receptor substrate 1 (IRS-1) as the proteolytic target of the CUL7 E3 ligase and uncovered CUL7 as a novel regulator of insulin signaling. Based on these observations, I will employ experimental strategies as outlined in this proposal to delineate CUL7`s role for the cellular insulin response and its contribution to insulin resistance and type 2 diabetes. ver más
31/12/2014
TUM
100K€

Línea de financiación: concedida

El organismo FP7 notifico la concesión del proyecto el día 2014-12-31
Presupuesto El presupuesto total del proyecto asciende a 100K€
Líder del proyecto
TECHNISCHE UNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5