Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

EnhanceRegen

Financiado

Rewiring gene regulatory circuits to enhance central nervous system repair

The mammalian central nervous system (CNS) is the epitome of complex cellular architecture. Still, it has a limited capacity to self-repair after an injury, which contrasts with the regenerative potential of the CNS in lower verte... ver más

30/04/2028

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-12-20

ERC-2022-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

1 Participantes

1.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

GRAIN Gene Regulatory Network Architecture in Neuronal Development 215K€ Cerrado

RegenerationFly Unraveling the cellular and molecular dynamics of adult neur... 157K€ Cerrado

EPIScOPE Reversing the epigenetic state of oligodendrocyte precursors... 2M€ Cerrado

SAF2012-31467 AN INTEGRATE GENOMIC APPROACH TO DEFINE A NOVEL NICHE IN DRO... 105K€ Cerrado

SAF2010-17167 ESTUDIO DE NUEVOS GENES IMPLICADOS EN LA NEUROGENESIS DESDE... 157K€ Cerrado

BFU2012-33506 CONTROL MOLECULAR DE LA DIFERENCIACION NEURONAL: APLICANDO N... 234K€ Cerrado

Duración del proyecto: 64 meses Fecha Inicio: 2022-12-20
Fecha Fin: 2028-04-30

Líder del proyecto

KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto The mammalian central nervous system (CNS) is the epitome of complex cellular architecture. Still, it has a limited capacity to self-repair after an injury, which contrasts with the regenerative potential of the CNS in lower vertebrates. Regeneration unfolds by the orchestrated triggering of developmental gene expression programs after injury. These programs are under the control of dedicated regeneration enhancer elements, which grant adult cells transcriptional access to developmental genes. Neural stem cells in the mammalian CNS lack the gene regulatory circuits that dictate when and where to activate the expression of developmental genes for regeneration. Consequently, most of the cells lost to injury are never replaced. This proposal aims to rewire mammalian gene expression circuits to endow neural stem cells with the capacity to activate regenerative responses after injury. First, building on innovative technologies, some of which that I developed, we will identify injury-responsive enhancer elements in the mouse spinal cord with single cell and spatiotemporal resolution. Then, using machine learning, we will decode the rules of injury-sensing DNA elements to design synthetic injury-responsive enhancers for precise gene expression control in neural stem cells. Finally, we will use synthetic enhancers in therapeutically relevant gene delivery systems to rewire gene circuits in order to promote the recruitment resident stem cells for cell replacement through the reactivation of developmental genes that would otherwise remain silent. The proposed research will uncover basic principles of gene regulation after CNS injury and open new avenues for the design of smart gene therapies for regenerative medicine using synthetic regeneration enhancers.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores