Regulation of lipid mediated immunity in the intestine
The gastrointestinal tract is continuously exposed to multiple antigens from commensal bacteria, food and pathogens. The mechanisms by which the gut mucosa tolerates trillions of commensal bacteria without developing inflammation...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
DEBUGGING-LPS
Deciphering and Exploiting the chemical features of Silent L...
2M€
Cerrado
NKT CELLS IN MUCOSA
NKT cells CD1 expression and lipid presentation in intestin...
222K€
Cerrado
MAIT
Evolutionary conserved T cells specific for a microbial meta...
185K€
Cerrado
ILCSIGNALLING
Deciphering cell cell and cell microbiome interactions of in...
171K€
Cerrado
SAF2010-16755
FUNCION DE LA INMUNIDAD INNATA EN LA TOLERANCIA INTESTINAL:...
133K€
Cerrado
GuT Memory
Engineered symbionts elucidate gut T cell memory and its (dy...
2M€
Cerrado
Información proyecto LIPID IMMUNITY
Duración del proyecto: 24 meses
Fecha Inicio: 2016-02-24
Fecha Fin: 2018-02-28
Líder del proyecto
KINGS COLLEGE LONDON
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
195K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
The gastrointestinal tract is continuously exposed to multiple antigens from commensal bacteria, food and pathogens. The mechanisms by which the gut mucosa tolerates trillions of commensal bacteria without developing inflammation remains poorly understood. It is increasingly appreciated that commensal bacteria-derived products regulate the homeostasis and/or function of many immune cell populations. Commensal bacteria-derived lipids are recognized by a population of unconventional T cells, called NKT cells. NKT cells specifically recognize through their T cell receptor lipid antigens presented by the MHC-I-like molecule CD1 which is expressed by a variety of immune cells within the intestinal tissue. Importantly, commensal-derived lipids modulate the numbers, phenotype and function of intestinal NKT cells. Conversely, dysregulation of NKT cell activation and/or CD1 expression have been associated with the development of colitis in mice and humans. Despite the abundance and diversity of microbial-derived lipids present in the gut, the molecular and cellular mechanisms that mediate their recognition by immune cells and the identity of the antigen presenting cells involved in this process remain unknown. By using a combination of multiparametric flow cytometry, genetic engineering and in vivo experiments this proposal aims to unravel the mechanisms and functional consequences of lipid-presentation in the mucosa. These studies will provide a better understanding of the factors that modulate intestinal immunity, with the potential to improve therapies for patients suffering from intestinal inflammatory diseases and possibly a broader range of disorders.