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GuT Memory

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Cerrado

Engineered symbionts elucidate gut T cell memory and its (dys)regulation

A detailed understanding of intestinal T cell memory is crucial for novel treatments against inflammatory bowel disease but also for efficient vaccine design. Th cells induced by the gut microbiota are important for pathogen defen... ver más

31/08/2029

UNI WUERZBURG

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

JULIUSMAXIMILIANSUNIVERSITAT WURZBURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-05-05

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNI WUERZBURG

1.60M€ | Lider

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Duración del proyecto: 63 meses Fecha Inicio: 2024-05-05
Fecha Fin: 2029-08-31

Líder del proyecto

JULIUSMAXIMILIANSUNIVERSITAT WURZBURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto A detailed understanding of intestinal T cell memory is crucial for novel treatments against inflammatory bowel disease but also for efficient vaccine design. Th cells induced by the gut microbiota are important for pathogen defence and tolerance, but it is unknown whether they form immunological memory characterised by long-term, antigen-independent maintenance. This has been due to the technical inability of disconnecting T cell induction from bacterial persistence in the gut. The GuT Memory project will yield unique insights into microbiota-directed Th cell memory and its (dys)regulation through uncoupling Th cell induction from luminal persistence of the microbe. Mutant strains of non-pathogenic gut bacteria engineered to transiently colonise germ-free mice will be combined with state-of-the-art adoptive transfer experiments to trace antigen-specific Th cells into the memory phase after their inducing bacterium has been cleared from the gut. With this, I aim to (1) elucidate how the longevity of such responses is regulated by host survival niches versus microbiota-mediated attrition. Uncovering (2) how the sequence of bacterial exposures and their microbial context shape the functional repertoire of such Th cells will demonstrate the impact of lineage flexibility on their protective versus pathogenic potential. (3) Ultimately, successive transient colonisations will provide a novel approach to dissect the physiological relevance of microbiota-specific memory Th cells for the luminal microbe, host protection, and epithelial function. These findings will aid mucosal vaccine design and indicate novel approaches to target pathogenic Th cells in chronic inflammatory disorders. The ground-breaking nature of this proposal lies in the innovation of being able to uncouple microbiota-mediated T cell induction from luminal antigen persistence to understand how T cell maintenance is fine-tuned to promote host–microbial mutualism while avoiding aberrant inflammation.

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