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Exosomes

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Regulated secretion and role of urinary nanovesicles

Extracellular nanovesicles called exosomes are small membrane-bound vesicles that are secreted by a variety of cell types. Exosomes contain various molecular constituents of their cell of origin, incl. proteins and genetic materia... ver más

31/08/2019

200K€

Presupuesto del proyecto: 200K€

Líder del proyecto

AARHUS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-08-31

MSCA-IF-2015-EF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 9 años

0% 100%

2 Participantes

200.19K€ | Lider

INDUMIX NUTRICIÓ

462.66K€ | Participante

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Duración del proyecto: 42 meses Fecha Inicio: 2016-02-23
Fecha Fin: 2019-08-31

Líder del proyecto

AARHUS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 200K€

Descripción del proyecto Extracellular nanovesicles called exosomes are small membrane-bound vesicles that are secreted by a variety of cell types. Exosomes contain various molecular constituents of their cell of origin, incl. proteins and genetic materials. The exosome release pathway contributes towards protein secretion, antigen presentation and pathogen transfer and roles of exosomes in intercellular communications and transfer of materials have been studied in immunology, neurobiology, stem cell and tumor biology. Exosomes are also released into the urine, although their role in urine is unclear and provides the basis of this fellowship. To gain novel information about urinary exosomes, a transdisciplinary approach is required. I will use my current knowledge of qualitative and quantitative proteomics combined with extensive bioinformatics to study urinary and renal exosomes and their ‘cargo’ secreted under normal and pathophysiological conditions. I will combine this information with new ideas and techniques I will learn in my host laboratory to examine rates of exosome secretion and to assess whether exosomes have the capacity to inhibit the growth of bacteria. Methodologies in this fellowship include techniques which I have extensive experience of e.g. large scale proteomic profiling, and novel techniques that I will learn in the host lab to enhance my research portfolio and future career prospects, including cell biological and microbiological techniques and experience in collecting/using samples from patients. The scientific goals of the project are to investigate the underlying mechanisms for regulated exosome secretion and the role of exosomes in innate immunity. As exosomes are secreted from multiple cell types, this study will have major implications for a variety of biology disciplines. The fellowship will develop my career by providing new novel laboratory skills, it will give me greater freedom to independently run a research project and increase my int collaborations.

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