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DNAmod_PROPAGATION

Financiado

Cerrado

Propagating DNA Modifications Across the Cell Cycle

Background DNA hydroxymethylation and methylation are marks on DNA that help define cell identity and maintain genome stability. DNA hydroxymethylation is recently discovered, and the mechanisms underlying its maintenance are unch... ver más

02/03/2021

UCPH

212K€

Presupuesto del proyecto: 212K€

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-03-02

MSCA-IF-2016: Individual Fellowships

I+D

Cerrada hace 8 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UCPH

212.19K€ | Lider

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Duración del proyecto: 47 meses Fecha Inicio: 2017-03-14
Fecha Fin: 2021-03-02

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 212K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Background DNA hydroxymethylation and methylation are marks on DNA that help define cell identity and maintain genome stability. DNA hydroxymethylation is recently discovered, and the mechanisms underlying its maintenance are uncharacterised. DNA methylation is crucial for cell function, but large blocks of DNA lose methylation in cancerous and ageing cells. It has been speculated that this is due to aberrant maintenance during cell division, however, technical limitations have prevented this from being directly assessed. By developing a novel technology to study maintenance of these marks, I will test this hypothesis for the first time. Approach This new technology will track how DNA methylation and hydroxymethylation patterns are restored after DNA replication, using both mass-spectrometry and genomics. Using this, I will track restoration of these marks following DNA replication, and test whether DNA methylation loss is caused by cell cycle speed, depleted methionine levels late in replication, or a combination of both. This will be followed up by functional analyses of key maintenance DNA hydroxymethylation and methylation factors. Thus, this work combines my past experience in DNA methylation with the host lab’s expertise in chromatin dynamics during DNA replication. Impact This will be the first quantitative study of how patterns of DNA methylation and DNA hydroxymethylation are propagated between cell divisions, which is essential to their roles in defining and maintaining cell identity. The results will bring seminal and novel understanding of these marks from both basic and biomedical perspectives, by elucidating how epigenome maintenance is linked to both DNA replication and the epigenetic changes seen in disease. By dissecting in unprecedented resolution the mechanisms underlying propagation of DNA methylation and hydroxymethylation, this work will unveil the basis for epigenetic inheritance of these marks between cell generations.

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