Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PRIME

Financiado

Cerrado

Polycomb repressor interactions in relation to the mammalian epigenome

"In mammals Polycomb group (PcG) repressors play a central role in maintaining cell type specific gene expression patterns in stem cells and through differentiation and development. Accordingly, deficiencies in the Polycomb system... ver más

31/01/2019

UOXF

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2019-01-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UOXF

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CANCER EPIGENETICS Comprehensive characterization of epigentic reprogramming in... 100K€ Cerrado

PRCTOERC Novel Regulatory Principles of Polycomb Repressive Complex 2 1M€ Cerrado

SAF2013-48926-P NUEVAS FUNCIONES DE LAS PROTEINAS POLYCOMB EN EL DESARROLLO,... 484K€ Cerrado

PREMORRIT The Polycomb Repression Complex 2 PRC2 Mechanisms of recr... 100K€ Cerrado

WaddingtonMemory Deciphering the role of regulatory factors driving epigeneti... 2M€ Cerrado

SAF2013-42252-R ANALISIS DEL MODELADO DE LA CROMATINA COMO PIEZA CLAVE TANTO... 242K€ Cerrado

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "In mammals Polycomb group (PcG) repressors play a central role in maintaining cell type specific gene expression patterns in stem cells and through differentiation and development. Accordingly, deficiencies in the Polycomb system are important in disease, notably in several types of cancer. Although it is established that the effector function of PcG proteins is in large part attributable to intrinsic histone modification activities, the mechanisms that target PcG proteins to defined loci remain poorly understood. A number of different models have been proposed in order to account for PcG targeting to CpG islands at the promoters of target genes, the inactive X chromosome, and in defined circumstances, to pericentric constitutive heterochromatin. Our recent studies, and those of others, have highlighted that underlying chromatin state and DNA methylation play an important role, and based on this we have developed a general model that can account for PcG localisation at all target loci. The central aim of this proposal is to test the general model and to determine the mechanisms by which underlying chromatin states dictate PcG factor binding. In a series of integrated experiments we will define chromatin modifications on mononucleosomes purified from PcG target loci, determine the activity of major PcG complexes in vitro using nucleosome templates assembled with recombinant histones/histone variants bearing specific chromatin modifications, and, using a novel photo-cross-linking strategy, define, at the atomic level, interactions of PcG complexes with chromatin templates in vitro. Finally, based on our findings we will establish de novo PcG target sites in cells and/or disrupt preexisting PcG target sites. These studies will help to define the fundamental mechanisms that determine PcG protein targeting, and in addition will provide insight into misregulation of PcG proteins in disease."

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores