Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PlasticAstros

Financiado

Cerrado

Plasticity at the tripartite synapse an in vivo study of astrocyte synapse inte...

Plasticity at the tripartite synapse an in vivo study of astrocyte synapse interactions in the mammalian cortex The appropriate functioning of the brain requires co-operation between its cellular constituents – neurons and glial cells. While neurons have been widely studied thanks to their electrical excitability, the glial component has be... ver más

30/06/2015

VLAAMS INSTITUUT...

235K€

Presupuesto del proyecto: 235K€

Líder del proyecto

VIB VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-06-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

VLAAMS INSTITUUT BIOTECHNOL...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

NEUROGLIA Molecular and cellular investigation of neuron astroglia int... 4M€ Cerrado

BFU2015-68655-P PLASTICIDAD SINAPTICA 225K€ Cerrado

ASTROSYN Roles of astrocytes in synaptic transmission and plasticity 100K€ Cerrado

PID2019-107677GB-I00 MECANISMOS CELULARES Y FUNCIONES DE LA PLASTICIDAD SINAPTICA 177K€ Cerrado

OMFLICSS Functional long term imaging of single bouton spine pairs du... 180K€ Cerrado

ANCoDy Delineation of experience-dependent astrocyte-neuron cogniti... 231K€ Cerrado

Líder del proyecto

VIB VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 235K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The appropriate functioning of the brain requires co-operation between its cellular constituents – neurons and glial cells. While neurons have been widely studied thanks to their electrical excitability, the glial component has been neglected for years. However, recent research has brought surprising results indicating that astrocytes (a type of glia) can actively regulate the structural and physiological properties of synapses. Unfortunately, most of the data regarding astrocyte function originates from ex vivo studies, because the complexity of the nervous system meant it was impossible to study astrocyte function in vivo with the limited technologies available at the time. It is recent advances in imaging, together with the introduction of novel, genetically modified animals, which now allow us to investigate astrocyte-synapse interactions in situ. In this multidisciplinary project, I will combine state-of-the-art genetic, biochemical and imaging techniques to study the role of astrocytes in mediating dendritic spine plasticity. First, I will develop a method that allows the flexible generation of genetically modified mice showing astrocyte-specific gene targeting. Second, using these mice I will analyze the dynamic relationship between astrocytic processes and dendritic spines in the mouse cortex in vivo, using 2-photon microscopy and a thinned-skull window. In parallel, I will perform an in vitro screen for astrocytic proteins involved in mediating physical contact with the synapse, by using unique subcellular fractionation techniques combined with mass-spectrometry. Finally, identified proteins will be knocked down with silencing RNA to study their role in astrocyte-synapse interactions in situ. This project will generate fundamental knowledge on how astrocytes influence the structure of neuronal networks in vivo. Such knowledge is essential if we are ever to successfully treat neurological conditions, such as schizophrenia, mental retardation and stroke.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores