Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

ANCoDy

Financiado

Delineation of experience-dependent astrocyte-neuron cognitive dynamics

In the brain, cells called astrocytes are as abundant as neurons, but are much less understood. Over the recent years, we have begun to appreciate how closely astrocytes support the development and function of synapses, the propos... ver más

31/08/2024

UCPH

231K€

Presupuesto del proyecto: 231K€

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-08-31

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021

I+D

Cerrada hace 3 años

0% 100%

1 Participantes

UCPH

230.77K€ | Lider

Proyectos interesantes

MICRO-COPS Microglia Control of Physiological Brain States 10M€ Cerrado

PCI2021-122069-2A INTERPRETING MEG BIOMARKERS OF ALZHEIMER S PROGRESSION WITH... 248K€ Cerrado

PID2021-124829NB-I00 ESPECIFICIDAD NEURONAL Y FUNCIONAL DE LOS CIRCUITOS HIPOCAMP... 394K€ Cerrado

STDP-development-AD Neuronal networks dynamics underlying spike timing precision... 181K€ Cerrado

PID2020-118386RA-I00 LOCALIZACION DE CAMBIOS CEREBRALES EL LA ENFERMEDAD DE ALZHE... 33K€ Cerrado

MEME Memory Engram Maintenance and Expression 2M€ Cerrado

Últimas noticias

27-11-2024: Videojuegos y creaci... Se abre la línea de ayuda pública: Ayudas para la promoción del sector del videojuego, del pódcast y otras formas de creación digital

27-11-2024: DGIPYME En las últimas 48 horas el Organismo DGIPYME ha otorgado 1 concesiones

27-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 2 concesiones

Duración del proyecto: 26 meses Fecha Inicio: 2022-06-13
Fecha Fin: 2024-08-31

Líder del proyecto

KOBENHAVNS UNIVERSITET

TRL 4-5

Presupuesto del proyecto 231K€

Descripción del proyecto In the brain, cells called astrocytes are as abundant as neurons, but are much less understood. Over the recent years, we have begun to appreciate how closely astrocytes support the development and function of synapses, the proposed substrate of memory. One emerging function of astrocytes is their direct involvement in learning and long-term memory. Indeed, astrocytic activity is affected in major brain disorders that affect memory, such as Alzheimer’s disease. The overarching aim of this fellowship is to study how astrocyte-neuron coordinated activity relates to learning and memory. I propose that astrocyte-neuron activity dynamics are shaped by learning over days to support memory formation. To test this hypothesis, I will use state-of-the-art microscopy and genetically encoded fluorescent proteins, both available in the host laboratory, to record the activity of large numbers of neurons and astrocytes while mice are trained in a perceptual learning task over days. In this way, I will be able to see how neurons and astrocytes change their activity in response to learning. I will then manipulate the activity of astrocytes using clever genetic tools and light, while the mice are being trained, and monitor the effects of this manipulation on the activity of neurons and memory performance. This step will allow me to establish causal links between astrocyte activity and memory. Finally, I will use modern statistical learning techniques to explore the contribution of astrocytes and astrocyte-neuron interactions to the computational capacity of the brain. This proposal capitalizes on my strong expertise in rodent behaviour and data analysis, my knowledge and strong interest on how experience shapes brain activity, and the established microscopy and genetic techniques in the host laboratory. Overall, this project will allow me to acquire new skills and knowledge in microscopy and astrocyte biology, and generate testable hypotheses for my future research.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores