Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

RECOGNIZE

Financiado

Cerrado

Physical principles of recognition in the immune system.

Receptor proteins on the surfaces of B- and T-cells interact with pathogens, recognize them and initiate an immune response. The diversity and complexity of immune receptors poses a challenge to nonequilibrium many-body physics an... ver más

31/10/2017

CNRS

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-10-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CNRS

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

SELFOR How our adaptive immune system separates self from foreig... 2M€ Cerrado

PID2019-106339GB-I00 BIOFISICA DE LA RESPUESTA INMUNE: RECEPTORES, CELULAS Y POBL... 35K€ Cerrado

PRE2020-092274 BIOFISICA DE LA RESPUESTA INMUNE: RECEPTORES, CELULAS Y POBL... 99K€ Cerrado

DNA RECOGNITION Recognition of viral DNA by the innate immune system 217K€ Cerrado

LYMPHOCYTECONTACTS Regulation and outcome of immune cell interactions in vivo 1M€ Cerrado

ImmunoMachines Unraveling the Supramolecular Architecture of Molecular Mach... 2M€ Cerrado

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Receptor proteins on the surfaces of B- and T-cells interact with pathogens, recognize them and initiate an immune response. The diversity and complexity of immune receptors poses a challenge to nonequilibrium many-body physics and our understanding of the physical principles that control the emergent functional properties of biological systems, such as recognition. The diversity of the composition of the immune repertoire emerges as a self-organized process, stimulated by interactions with the environment. The goal of the proposed research is to study the self-organization of the immune repertoire in the face of its pathogenic environment at the molecular and evolutionary level, by using a combination of data analysis and statistical mechanics modeling. Recent experiments have determined the set of B-cell receptors found in a zebrafish and T-cells in humans – data that allows for theoretical analysis and hypotheses rejection that were never possible before. I will theoretically study the problem of recognition from four unique and complementary directions: - guided by statistical signatures in the data I will propose evolutionary models of how selection and mutation in the sequences lead from the genomic precursors to a functional repertoire of receptors, - I will quantify, under simplifying assumptions, the question of the optimal repertoire for recognition in a varying but partially predictable pathogenic environment using maximum likelihood, - analyzing sequence data I will build probabilistic models to characterize the molecular scenarios that generate the repertoire, - I will use information theory and statistical methods to build data-driven models of the molecular nature of recognition based on yeast display experiments. Describing interactions between elements of receptor sequences will be an important step towards a physical understanding of recognition in the immune system, a crucial concept in grasping the onset of allergies and auto-immune diseases.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores