Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

POLAR

Financiado

Phagosomal LC3's Alternative Role

The opportunistic fungus Aspergillus fumigatus is an emerging cause of life-threatening respiratory infections in an expanding group of patients with acquired innate immune defects. Dissecting the molecular dynamics of fungal-host... ver más

31/08/2026

FOUNDATION FOR RES...

153K€

Presupuesto del proyecto: 153K€

Líder del proyecto

IDRYMA TECHNOLOGIAS KAI EREVNAS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-29

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-WIDERA-2023-TALENTS-02-01: ERA Fellowships

I+D

Cerrada hace 1 año

0% 100%

1 Participantes

FOUNDATION FOR RESEARCH AND...

153.49K€ | Lider

Proyectos interesantes

BFU2010-22172 REGULACION DE LA ADQUISICION DE ZINC POR ASPERGILLUS FUMIGAT... 121K€ Cerrado

PID2019-110994RB-I00 RELACION ENTRE REGULACION DE HOMEOSTASIS DE ZINC, BIOSINTESI... 178K€ Cerrado

MycoViralPath The role of fungal viruses in shaping fungal pathogenesis an... 2M€ Cerrado

SAF2013-48382-R EXPLORACION DE LA INHIBICION DE LA ADQUISICION Y REGULACION... 97K€ Cerrado

iMAC-FUN Dissecting novel mechanisms of iron regulation during macrop... 2M€ Cerrado

SAF2008-04143 DETECCION Y ESTUDIO DE LOS MECANISMOS DE RESISTENCIA A LOS A... 54K€ Cerrado

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 28 meses Fecha Inicio: 2024-04-29
Fecha Fin: 2026-08-31

Líder del proyecto

IDRYMA TECHNOLOGIAS KAI EREVNAS

TRL 4-5

Presupuesto del proyecto 153K€

Descripción del proyecto The opportunistic fungus Aspergillus fumigatus is an emerging cause of life-threatening respiratory infections in an expanding group of patients with acquired innate immune defects. Dissecting the molecular dynamics of fungal-host interplay mediating sterilizing immunity against A. fumigatus is crucial to gain insight in disease pathogenesis and develop novel immunomodulatory therapies. Physiologically, Aspergillus fumigatus conidia are eliminated inside Alveolar Macrophages (AMs) via activation of the LC3 associated phagocytosis (LAP) pathway. A. fumigatus cell wall melanin blocks LAP to promote pathogenicity. Intracellular germination of A. fumigatus conidia results in exposure of immunostimulatory fungal molecules concomitantly with melanin removal and triggers NADPH oxidase-dependent activation of LAP. The molecular mechanism of LC3 conjugation on A. fumigatus phagosome membrane and the physiological function of LAP on AM biology and antifungal host defense remain elusive. Of interest, pilot studies in the host lab demonstrate that infection of AMs and other types of macrophages with live conidia of A. fumigatus results in a unique pattern of pulsatile LC3 recruitment on the phagosome membrane, which is accompanied by waves of increased phagosome permeability. These findings imply for a novel mechanism of LC3+ phagosome (LAPosome) formation via cytosolic sensing of fungal vita-PAMPs and suggests for an unconventional function of LAPosomes in regulation of membrane repair mechanisms in response to damage induced by Aspergillus infection. This research project aims to understand the precise host and pathogen molecular determinants of LAPosome formation and exploit the intriguing role of LC3 on regulation of phagosomal membrane repair during A. fumigatus infection. Using A. fumigatus as a model pathogen, this project with provide fundamental insights on the role of LAP in macrophage biology paving the way for new host-directed strategies.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores