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TRANSLATOMICS

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Painting the landscape of translational control of gene expression through meta...

Painting the landscape of translational control of gene expression through meta analysis of genome wide data sets Translational control determines the rate at which mRNAs are synthesized into proteins; regulates biological processes ranging from apoptosis to memory; and shows deregulation in diseases such as fibrosis and cancer. In cancer, dy... ver más

31/03/2015

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-03-31 No tenemos la información de la convocatoria

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1 Participantes

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Líder del proyecto

KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Translational control determines the rate at which mRNAs are synthesized into proteins; regulates biological processes ranging from apoptosis to memory; and shows deregulation in diseases such as fibrosis and cancer. In cancer, dysregulated translational control is associated with worse prognosis in most sold cancer. Despite this, integrated genome wide knowledge of translational control and its regulatory mechanisms is lacking. My new methods for data analysis and mechanistic discoveries allow, for the first time, efficient genome wide studies of translational control. By using all publicly available genome-wide data sets and these methods we will characterize the landscape of translational control by identifying genes and pathways that are regulated translationally; groups of genes that constitute functional translational modules and show co-regulation across many biological conditions; key genes that are highly connected (nodes) and under translational control; network structures that are regulated at the translational level; and mechanisms that mediate such regulation. This information will be used to compare many biological processes to generate an integrated perspective of translational control. Through functional experiments employing both gene specific and regulatory mechanism focused approaches we will link translational control, genes, mechanisms for regulation and biological processes to unravel a new level of understanding of translational control. Such knowledge will be applicable in future studies of how dysregulation of translational control contributes to human disease.

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