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RiboTrace

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Bridging temporal resolution gaps to dissect RNA silencing at the molecular and...

Bridging temporal resolution gaps to dissect RNA silencing at the molecular and genomic scale The implementation of distinct gene expression profiles is essential for organismal development, physiological responses to external stimuli or pathogens, and defines a primary cause for human disease. While much attention has bee... ver más

31/01/2025

UNIVIE

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITAT WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2025-01-31

ERC-2019-COG: ERC Consolidator Grant

I+D

Cerrada hace 5 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

UNIVIE

1.45M€ | Lider

PLASTIENVASE

337.11K€ | Participante

IMBA

550.33K€ | Participante

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Duración del proyecto: 60 meses Fecha Inicio: 2020-01-23
Fecha Fin: 2025-01-31

Líder del proyecto

UNIVERSITAT WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The implementation of distinct gene expression profiles is essential for organismal development, physiological responses to external stimuli or pathogens, and defines a primary cause for human disease. While much attention has been paid to the regulation of transcription, the control over RNA fate and function has only recently emerged as a central hallmark of gene regulation with enormous biological, technological and biomedical implications. Here, we propose to study the molecular principles of RNA silencing, the least understood aspect of post-transcriptional gene regulation. We aim to systematically dissect the mechanisms and biological functions of RNA 3´end uridylation to determine the emerging role of RNA modifications in the regulation of gene expression; we will elucidate fundamental principles of RNA turnover at the genomic scale by time-resolved transcriptomics; and we will use functional genomics and haploid genetics to systematically delineate post-transcriptional gene regulatory pathways. Throughout, we will link our results back to the established function of RNA silencing in the control of organismal development, physiology and disease. Our goal is to acquire fundamental insights into the processes that survey the quality and quantity of the transcriptome to determine possible molecular causes for aberrant RNA levels that have been associated with diverse human diseases. Because of its genetic and biochemical tools, we will use Drosophila melanogaster as a model organism. We will employ a combination of in vivo genetics, cell-free biochemical experiments, bioinformatics, and cell culture methods. What we learn in flies we will test for its conservation in mammalian cell extracts and cultured cells. Overall, we will determine fundamental biological mechanisms of gene regulation trough pathways with enormous biological impact in health and disease.

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