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DAMONA

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Mutation and Recombination in the Cattle Germline Genomic Analysis and Impact o...

Mutation and Recombination in the Cattle Germline Genomic Analysis and Impact on Fertility Mutation and recombination are fundamental biological processes that determine adaptability of populations. The mutation rate reflects the equilibrium between the need to adapt, the burden of mutation load, the cost of fidelity, a... ver más

28/02/2018

ULIEGE

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITE DE LIEGE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2018-02-28 No tenemos la información de la convocatoria

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1 Participantes

ULIEGE

0.00€ | Lider

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Líder del proyecto

UNIVERSITE DE LIEGE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Mutation and recombination are fundamental biological processes that determine adaptability of populations. The mutation rate reflects the equilibrium between the need to adapt, the burden of mutation load, the cost of fidelity, and random drift that determines a lower limit in achievable fidelity. Recombination fulfills an essential mechanistic role during meiosis, ensuring proper chromosomal segregation. Recombination affects the rate of creation and loss of favorable haplotypes, imposing 2nd-order selection pressure on modifiers of recombination. It is becoming apparent that recombination and mutation rates vary between individuals, and that these differences are in part inherited. Both processes are therefore evolvable, and amenable to genomic analysis. Identifying genetic determinants underlying these differences will provide insights in the regulation of mutation and recombination. The mutational load, and in particular the number of lethal equivalents per individual, remains poorly defined as epidemiological and molecular data yield estimates that differ by one order of magnitude. A relationship between recombination and fertility has been reported in women but awaits confirmation. Population structure (small effective population size; large harems), phenotypic data collection (systematic recording of > 50 traits on millions of cows), and large-scale SNP genotyping (for genomic selection), make cattle populations uniquely suited for genetic analysis. DAMONA proposes to exploit these unique resources, combined with recent advances in next generation sequencing and genotyping, to: (i) quantify and characterize inter-individual variation in male and female mutation and recombination rates, (ii) map, fine-map and identify causative genes underlying QTL for these four phenotypes, (iii) test the effect of loss-of-function variants on >50 traits including fertility, and (iv) study the effect of variation in recombination on fertility.

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