Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FUNCTION OF CAVEOLAE

Financiado

Cerrado

MOLECULAR MECHANISM OF CAVEOLAR STRUCTURE AND FUNCTION

Caveolae are small invaginations of the plasma membrane, with characteristic flask-shaped morphology, found in most mammalian cells. Phenotypes of mice lacking genes for caveolins, key protein components of caveolae, show that the... ver más

11/07/2015

NC3Rs

209K€

Presupuesto del proyecto: 209K€

Líder del proyecto

National Centre for the Replacement Refinemen... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-07-11 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

NC3Rs

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BES-2012-052980 CAVEOLINA-1 EN TRAFICO DE MEMBRANA, MECANOTRANSDUCCION Y SEÑ... 43K€ Cerrado

SAF2011-25047 CAVEOLINA-1 EN TRAFICO DE MEMBRANA, MECANOTRANSDUCCION Y SEÑ... 484K€ Cerrado

BES-2010-038041 ESTUDIO DEL DEL TRAFICO INTRACELULAR DE CAVEOLINA, FORMACION... 43K€ Cerrado

BFU2009-10335 ESTUDIO DEL DEL TRAFICO INTRACELULAR DE CAVEOLINA, FORMACION... 359K€ Cerrado

PM-NANOMAPS Dynamic spatial organization of plasma membrane proteins at... 162K€ Cerrado

HYDROBIOMEM Hydrodynamics of Double Membrane Spreading in Biology 211K€ Cerrado

Líder del proyecto

National Centre for the Replacement Refinemen... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 209K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Caveolae are small invaginations of the plasma membrane, with characteristic flask-shaped morphology, found in most mammalian cells. Phenotypes of mice lacking genes for caveolins, key protein components of caveolae, show that these structures are involved in many physiological processes, such as vesicle trafficking, cholesterol homeostasis, signal transduction, tumor suppression and mechanosensing. However, many proposed physiological roles for caveolae are controversial, making a rigorous analysis of their function vital. The molecular mechanisms underlying the physiological functions of caveolae are not well understood as well, in part because until recently, the study was restricted to only one candidate-the family of caveolin proteins. The recent identification of a family of cavins genes as another essential structural component of caveolae has enabled us to explore caveolar research. Salient properties of the cavin family include their ability to form complexes and different but overlapping tissue distribution. The discovery of cavins support the idea that the wide range of functions attributed to caveolae in various tissues require diverse set of proteins. To address it, I will utilize innovative techniques for either high throughput screening aimed to identify novel factors or for characterization the role of cavins in this process. I will characterize cavin complexes in-vitro and in-vivo, by testing their interacting partners, the stoichiometry and domain requirements for this binding. Next, I will look for correlations between cavins complex characteristics in different tissues and changes in caveolar structure. As my long-term goal I plan to link between the protein composition of caveolae and their function in different tissues. This study will provide new insights into caveolar function in different tissues, thus advancing our understanding of the physiological processes shown to require proper function of these enigmatic structures.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores