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NanoMechShape

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Molecular control of actin network architecture and mechanics during cell shape...

Molecular control of actin network architecture and mechanics during cell shape changes Precise control of shape is key to cell physiology, and cell shape deregulation is at the heart of many pathologies. As cell morphology is controlled by forces, studies integrating physics with biology are required to truly unders... ver más

30/04/2025

THE CHANCELLOR MAS...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-03-29

ERC-2018-COG: ERC Consolidator Grant

I+D

Cerrada hace 6 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

THE CHANCELLOR MASTERS AND S...

1.94M€ | Lider

AGUA RESIDUOS Y MEDIO AMBIEN...

497.76K€ | Participante

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Duración del proyecto: 73 meses Fecha Inicio: 2019-03-29
Fecha Fin: 2025-04-30

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Precise control of shape is key to cell physiology, and cell shape deregulation is at the heart of many pathologies. As cell morphology is controlled by forces, studies integrating physics with biology are required to truly understand morphogenesis. NanoMechShape will take such an interdisciplinary approach to investigate the regulation of animal cell shape. In animal cells, actin networks are the primary determinants of shape. Most cell shape changes fall into two categories: 1) those driven by contractions of the actin cortex, a thin network underlying the membrane in rounded cells; and 2) those resulting from transitions between the cortex and other actin networks, such as lamellipodia and filopodia. To understand cell deformations, it is thus essential to understand the regulation of cortex contractile tension and the mechanisms controlling transitions in actin architecture. NanoMechShape will comprise three aims. First, we will explore how cortex tension is regulated. We will focus on the role of cortex architecture, which remains elusive due to the difficulty in probing the organisation of the thin cortical network. We will unveil cortex architecture using super-resolution and electron microscopy, and systematically investigate how nanoscale architectural features affect tension. Second, we will explore how the identified regulatory mechanisms contribute to the establishment of a cortical tension gradient. We will focus on the gradient driving cytokinetic furrow ingression, an exemplar tension-driven shape change. Third, we will investigate transitions in actin architecture underlying cell spreading. We will compare spreading at the end of mitosis and during differentiation of mouse embryonic stem cells, paving the way to investigations of the crosstalk between cell shape and fate. By bridging a fundamental gap between molecular processes and cell-scale behaviors, our multidisciplinary study will unveil some of the fundamental principles of cell morphogenesis.

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