Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MORPHOCORDIV

Financiado

Cerrado

The inherent morphological potential of the actin cortex and the mechanics of sh...

The inherent morphological potential of the actin cortex and the mechanics of shape control during cell division The shape of animal cells is primarily determined by the cellular cortex, a cross-linked network of actin and myosin lying directly beneath the plasma membrane. Although it is increasingly clear that the study of cell mechanics is... ver más

28/02/2018

UNIVERSITY COLLEGE...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITY COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2018-02-28 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIVERSITY COLLEGE LONDON

0.00€ | Lider

Proyectos interesantes

PID2019-109013GB-I00

Medical Technol...

Applied Physics

242K€ Cerrado

ACTMECH

Medical Technol...

Applied Physics

2M€ Cerrado

PID2020-116141GB-I00

Medical Technol...

Applied Physics

145K€ Cerrado

DROSOFORCESPOLARITY

Medical Technol...

Applied Physics

169K€ Cerrado

TensionControl

Medical Technol...

Applied Physics

2M€ Cerrado

RYC-2010-07361

Medical Technol...

Applied Physics

192K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

UNIVERSITY COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The shape of animal cells is primarily determined by the cellular cortex, a cross-linked network of actin and myosin lying directly beneath the plasma membrane. Although it is increasingly clear that the study of cell mechanics is essential to understand cellular morphogenesis, the physical properties of the cortex are poorly understood. Our previous study on the mechanics of cytokinesis identified cortex tension, network turnover and cellular elasticity as key mechanical parameters controlling cell morphology. A physical description coupling cortex mechanics to cellular shape changes indicates that modulation of these three key parameters could be sufficient to induce a variety of morphological behaviors, including symmetric ingression of a contractile ring, cortex oscillations, and even asymmetric cell cleavage. The aim of this proposal is to reveal the intrinsic shape-generating potential of the cortex and to understand how this potential is used and controlled during cell division. To do so, we will first investigate how cortex tension, turnover and cell elasticity are controlled throughout division. We will test our understanding of cell shape mechanics by exploring how perturbing these properties affects the shape of the dividing cell. We will then explore whether cortical contractions can lead to asymmetric cytokinesis by attempting to induce differences in size between daughter cells by mechanical perturbations. Finally, we will use blebs separated from cells as model isolated cortices and investigate the control of shape dynamics in this simplified system. Our interdisciplinary approach will produce an integrated description of the mechanical function of the cortex in cell shape changes. More generally, I expect that this work will unveil some of the fundamental principles of cell morphogenesis by resolving how the coordinated regulation of a single set of physical parameters can unify seemingly disparate cellular morphogenetic events.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores