Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

EpiPhys

Financiado

Physics of the first mammalian epithelium

Epithelia operate major biological functions throughout the human body. Forming de novo during preimplantation development, the trophectoderm (TE) is our first epithelium. The TE mediates the formation of the first mammalian lumen... ver más

31/12/2028

CNRS

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-07-18

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CNRS

2.00M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CNS2023-145460 Física aplicada y Biofísica 166K€ Cerrado

PushingCell Pushing from within: Control of cell shape, integrity and mo... 10M€ Cerrado

FEM4Embryo New implicit-surface Finite Element Methods to discover univ... 212K€ Cerrado

BES-2015-071280 Molecular and cellular biophysics of adhesion 93K€ Cerrado

CNS2023-143803 Física aplicada y Biofísica 199K€ Cerrado

MechMCA Mechanics of the Membrane-Cortex Attachment 196K€ Cerrado

Duración del proyecto: 65 meses Fecha Inicio: 2023-07-18
Fecha Fin: 2028-12-31

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Epithelia operate major biological functions throughout the human body. Forming de novo during preimplantation development, the trophectoderm (TE) is our first epithelium. The TE mediates the formation of the first mammalian lumen, which involves considerable physical challenges. Indeed, pressurized fluid, pumped through the TE, fractures intercellular contacts before cells squeeze this fluid into a single lumen. We recently found that cell adhesion and cell contractility determine the position of this lumen, which then controls further differentiation of the TE. This suggests that physical cues can determine the first mammalian axis of symmetry and TE patterning. However, most physical properties of epithelia controlling this process remain unknown, as their study in vivo has been so far very limited. In this project, we will investigate how the physics of the TE shapes and patterns the mouse preimplantation embryo, by using novel approaches, such as microfluidics and optical tweezers, that allow direct measurement of physical properties in vivo. First, we will determine epithelial transport properties of the TE and their regulation during lumen opening. We will next map plasma membrane reservoirs and membrane mechanics during preimplantation development. We will then characterize how the nuclear envelope and chromatin regulate nuclear mechanics during epithelial thinning. With this broad and unprecedented in vivo physical characterization, we will determine how epithelial transport, plasma membrane and nuclear mechanics influence epithelial stretching and patterning during lumen growth and positioning. Finally, we will determine the relative contributions of these physical properties in this process, and investigate their relationship. Together, we will build an integrated view of how uncharted physical properties of epithelia control stretching and patterning, in the context of a process that is key to the fertility of the ageing European population.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores