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FEM4Embryo

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New implicit-surface Finite Element Methods to discover universal mechanisms of...

New implicit-surface Finite Element Methods to discover universal mechanisms of animal embryo development All living organisms emerge from a single cell, the zygote. In early embryo development of animals, the interplay of cell surface dynamics, polarity proteins and intracellular flows forms distinct polarity domains, which the cell... ver más

30/04/2025

CNRS

212K€

Presupuesto del proyecto: 212K€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-16

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

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1 Participantes

CNRS

211.75K€ | Lider

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Duración del proyecto: 25 meses Fecha Inicio: 2023-03-16
Fecha Fin: 2025-04-30

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 212K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto All living organisms emerge from a single cell, the zygote. In early embryo development of animals, the interplay of cell surface dynamics, polarity proteins and intracellular flows forms distinct polarity domains, which the cell uses to specify the fate of its daughter cells. A classical biological model to learn how animal cells polarise is the 1-mm long C. elegans roundworm. Establishment of cell polarity in the C. elegans zygote is well studied, yet the biophysical mechanisms controlling cell polarity beyond that stage remain largely unexplored. Biophysical experiments and Finite Element (FE) models could together elucidate this matter. However, FE models of multicellular morphogenesis, other than rare, rely on explicit surface descriptions. Explicit methods are not ideal to simulate cell polarity at the multicellular scale, because they can hardly deal simultaneously with 3D foamlike geometries, coupled surface-bulk physics and topology changes. Conversely, FE methods based on implicit surfaces have recently shown convincing potential to bypass this weakness. In this project, I will launch a new implicit-surface FE paradigm to simulate early embryo development and I will apply it to gain new insights on the patterning of C. elegans embryos. To this end, I will pioneer implicit-surface FE methods for coupled surface-bulk dynamics in foamlike geometries. The success of the project is ensured by joining leading expertise in implicit-surface FEs from myself, biophysics of morphogenesis from my supervisor, and patterning in C. elegans embryos from my external collaborator. I will be based at the Center for Interdisciplinary Research in Biology of the CNRS, located at Collège de France; a unique and ideal place to create new synergies between a FE researcher like me, biophysicists and cell biologists, as well as to grow and diversify my scientific and transferrable skills to become one of the few independent leaders in FEs for multicellular morphogenesis in Europe.

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