Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SYNAPSE STABILITY

Financiado

Cerrado

Molecular Analysis of Synapse Formation Maintenance and Disassembly at the Dros...

Molecular Analysis of Synapse Formation Maintenance and Disassembly at the Drosophila neuromuscular junction The refinement of neuronal circuits requires both a stabilization of existing synaptic connections and a disassembly of previously functional synapses. While the mechanisms of synapse formation have been extensively studied, very... ver más

31/05/2012

FMI

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

Novartis Forschungsstiftung No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-05-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FMI

100.00K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2019-106615RB-I00 INTERACTOMA Y TRANSCRIPTOMA SINAPTICOS DEL FACTOR SINAPTONUC... 296K€ Cerrado

Syncrip_2014 The molecular basis of learning and memory uncovering the l... 183K€ Cerrado

PID2019-110952GB-I00 HOUSE KEEPING GENES KEEPING EVERY NEURON DIFFERENT 109K€ Cerrado

Neuronal Trafficking Mechanisms of synaptic growth and plasticity 161K€ Cerrado

BFU2015-65685-P SEÑALES MOLECULARES SINAPTOGENICAS ENTRE NEURONAS Y GLIA 261K€ Cerrado

SynLink Molecular Structure and Engineering of Synaptic Organizer Pr... 1M€ Cerrado

Líder del proyecto

Novartis Forschungsstiftung No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The refinement of neuronal circuits requires both a stabilization of existing synaptic connections and a disassembly of previously functional synapses. While the mechanisms of synapse formation have been extensively studied, very little is known about the molecular mechanisms that are responsible for the stabilization of synaptic connections. Any inappropriate loss of synaptic stability will lead to disruptions of neuronal circuits and finally to neurodegenerative disease. Therefore, the identification of the molecular mechanisms that regulate synapse stability versus disassembly may help to understand how synaptic circuits are modified in response to signaling events and may provide useful insights towards our understanding of neurodegenerative disease. I am combining the advantages of Drosophila genetics, cell biology and physiology with a high-resolution assay for synapse retraction to identify and characterize genes involved in synapse formation, stability and disassembly. My postdoctoral work has highlighted the importance of a presynaptic cytoskeletal network that links cell adhesion molecules to the underlying actin and microtubule cytoskeleton to achieve normal synapse formation and stability. Here I propose to define the signaling systems that control the assembly and stability of the presynaptic network during synapse formation and maintenance. In the first aim I will focus on the adaptor molecule Ankyrin2 that has the potential to directly link synaptic cell adhesion molecules to the presynaptic microtubule cytoskeleton. The second aim addresses how actin dynamics contribute to normal synapse formation and stability. Finally, I will use forward genetic approaches to identify novel molecules required for synaptic stability. Together these projects will provide insights into the molecular mechanisms that regulate synapse stability in response to intrinsic and extrinsic signaling systems within neuronal circuits.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores