Micro and Macrocirculation Coupling a cross sectional investigation of the cro...
Micro and Macrocirculation Coupling a cross sectional investigation of the cross talk between the two circuits in insulin resistance states
"Background: The human micro- and macrocirculation have distinct vital roles in the homeostasis of the cardiovascular system. There is a cross-talk between the two circuits to achieve the adequate vascular adaptations. Reciprocal...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
ANGIOMIRS
microRNAs in vascular homeostasis
2M€
Cerrado
SAF2013-43302-R
¿ES EL ESTADO FUNCIONAL DE LAS CELULAS ENDOTELIALES MICROVAS...
194K€
Cerrado
SAF2016-77222-R
VITAMINA D EN LA HIPERTENSION PULMONAR
169K€
Cerrado
SAF2008-00031
MODELOS ANIMALES Y CELULARES DE RESISTENCIA A LA INSULINA: D...
327K€
Cerrado
SICA-HF
Studies Investigating Co morbidities Aggravating Heart Failu...
6M€
Cerrado
PDC2022-133658-I00
PLATAFORMA MINIATURIZADA PARA LA MODELIZACION Y VALIDACION D...
138K€
Cerrado
Información proyecto MMC
Líder del proyecto
UNIVERSITEIT MAASTRICHT
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
255K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
"Background: The human micro- and macrocirculation have distinct vital roles in the homeostasis of the cardiovascular system. There is a cross-talk between the two circuits to achieve the adequate vascular adaptations. Reciprocal transduction of ills signal between the micro- and macrocirculation may impair their optimal coupling and further accelerate vascular disease. In Europe the prevalence of insulin resistance (IR) (obesity and diabetes type 2) states and the related vascular damage and mortality is increasing rapidly. Main Scientific objective: to identify the early events in the natural history of chronic vascular disease of the micro- and macrocirculation in IR states and to investigate of the adaptive process of each circuit to the other in order to maintain optimal coupling. Specific scientific objectives: investigation of the cross-talk between wave reflections, pressure amplification, blood pressure phenotypes and blood flow patterns (conduit arteries, skin, muscle, retina) and their relation to the function and structure of large/small arteries, arterioles and cappilaries, endothelial function. Main training Objective: trained-through-research under supervision and hands-on training on microcirculation novel techniques; supervision of the investigations on macrocirculation. Study design: observational, population-based cross sectional study. Study population: random sample (1200 subjects) of Maastricht's area population with and without IR states, age 40-75. Microcirculation: skin videomicroscopy, retinamicroscopy, skin laser doppler and fourier analyses, muscle contrast-enhanced ultrasound,Macrocirculation: pulse wave analysis (mathematic applications-wave separation analysis), pulse wave velocity, carotid/brachial ultrasound, Other methods: All participants will be phenotyped by means of questionnaire, biood, urine, anthropometry, electrocardiogran and echocardiography.
Expected results: to identify the very early events and the adaptive processes"