Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

HOTMEIOSIS

Financiado

Cerrado

Meiotic recombination How where and why? Mechanisms and Implications

During meiosis, homologous recombination plays a mechanical role by connecting homologous chromosomes, thus allowing proper chromosome segregation during the first meiotic division. In most species, the absence of meiotic recombin... ver más

31/08/2018

CNRS

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2018-08-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CNRS

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BrokenGenome Breaking and rebuilding the genome mechanistic rules for th... 1M€ Cerrado

DSBSunrise Identifying the steps required for meiotic DNA double strand... 2M€ Cerrado

CGL2014-53106-P LA MEIOSIS Y LA EVOLUCION DE LOS CROMOSOMAS SEXUALES EN MAMI... 186K€ Cerrado

CrossOver Meiotic crossing over from spatial distribution to in situ... 2M€ Cerrado

BFU2012-35748 EL "CHECKPOINT" DE RECOMBINACION MEIOTICA: REGULACION EPIGEN... 126K€ Cerrado

PRDM9Recomb The Evolution of PRDM9 Binding and Genomic Localization of M... 195K€ Cerrado

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto During meiosis, homologous recombination plays a mechanical role by connecting homologous chromosomes, thus allowing proper chromosome segregation during the first meiotic division. In most species, the absence of meiotic recombination leads to sterility. In addition, recombination generates new combinations of alleles, increases genome diversity and plays a major role in genome evolution. Meiotic recombination is initiated by the programmed induction of DNA double-strand breaks (DSBs), but how these events are controlled at the molecular level and how they are constrained by selective pressures during evolution is not understood. Our recent historical discovery that the Prdm9 gene controls the localization of recombination in the mouse and human genomes revolutionizes our view on this process, with one main unanticipated finding: the highly dynamic and fast evolution of Prdm9 and of meiotic DSB sites in the genome. Understanding meiotic recombination clearly requires the development of novel approaches to analyze this process from both molecular and evolutionary perspectives. To this aim, we will develop an extensive analysis of Prdm9 as its activity, role, regulators and sites of action in the genome need to be identified and understood in order to gain insight into its dynamics and evolution. We will develop a unique and challenging strategy to overcome the limitation of laboratory mice and pioneer the analysis of Prdm9 and recombination activity in wild mice. We thus aim at making a breakthrough in the field by bringing molecular genetics and evolutionary biology together, to grasp the significance of meiotic recombination for genome evolution and sexual reproduction in eukaryotes.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores