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Mechanism of Type 9 Secretion an unusual protein transport system involved in p...

Mechanism of Type 9 Secretion an unusual protein transport system involved in pathogenesis and motility The recently-discovered Type IX Secretion System (T9SS) is a protein transport pathway that exports proteins across the outer membrane of Gram-negative of the phylum Bacteroidetes. It is an essential pathogenicity determinant in s... ver más

28/02/2025

UOXF

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-04-23

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2018-ADG: ERC Advanced Grant

I+D

Cerrada hace 6 años

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2 Participantes

UOXF

2.25M€ | Lider

COMPOSAN CONSTRUCCION S.A.

450.66K€ | Participante

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Últimas noticias

02-12-2024: AGENCIA-VALENCIANA-D... En las últimas 48 horas el Organismo AGENCIA VALENCIANA D... ha otorgado 1 concesiones

02-12-2024: CDTI En las últimas 48 horas el Organismo CDTI ha otorgado 4 concesiones

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

Duración del proyecto: 70 meses Fecha Inicio: 2019-04-23
Fecha Fin: 2025-02-28

Presupuesto del proyecto 2M€

Descripción del proyecto The recently-discovered Type IX Secretion System (T9SS) is a protein transport pathway that exports proteins across the outer membrane of Gram-negative of the phylum Bacteroidetes. It is an essential pathogenicity determinant in severe periodontal disease and in the major bacterial diseases of farmed fish. It is also required for the unique Bacteroidete gliding motility. The components required to catalyse T9SS export are still not fully defined, but include at least 18 authenticated proteins. Possible functions can currently only be assigned to some of these T9SS components. However, it is clear that the pathway involves a number of interacting protein complexes. Our current understanding of the T9SS is superficial and lacking in molecular level structural and mechanistic detail. In a landmark recent study we have identified and structurally characterized the multi-protein outer membrane protein conducting channel of the T9SS. Our ambitious goal is to apply similar state-of-the-art experimental methods to systematically characterise the full T9SS pathway. We will systematically characterise the component protein complexes that make up the T9SS by: - Defining their composition through co-purification from native sources. - Determining their molecular structures by cryo-EM. - Assessing their dynamic interactions through live cell fluorescence imaging, biochemical experiments, and structural characterization. In addition, we will use single molecule tracking methods to follow substrate molecules through the steps of the T9SS transport cycle in real time in live bacterial cells and apply this methodology to elucidate T9SS mechanism.

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