Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MatrixMacrophages

Financiado

Cerrado

Matrix degrading macrophages in cancer growth and invasion

Solid tumors consist of malignant cancer cells in constant interaction with the extracellular matrix and different types of non-malignant cells. Notably, these cells include macrophages which, during cancer progression, take part... ver más

30/06/2017

UCPH

212K€

Presupuesto del proyecto: 212K€

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2017-06-30

MSCA-IF-2014-EF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 10 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UCPH

212.19K€ | Lider

Proyectos interesantes

PID2021-122292NA-I00

Medical Technol...

Data Science

248K€ Cerrado

MetaMacNiche

Medical Technol...

Data Science

176K€ Cerrado

X-TAM

Medical Technol...

Data Science

1M€ Cerrado

Recruit

Medical Technol...

Data Science

261K€ Cerrado

FOLOME

Medical Technol...

Data Science

2M€ Cerrado

CNS2023-145020

Medical Technol...

Data Science

200K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 26 meses Fecha Inicio: 2015-04-13
Fecha Fin: 2017-06-30

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 212K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Solid tumors consist of malignant cancer cells in constant interaction with the extracellular matrix and different types of non-malignant cells. Notably, these cells include macrophages which, during cancer progression, take part in an extensive degradation of the extracellular matrix. This process leads to destruction of the normal tissue and facilitates metastatic spread. It is now evident that tumor-infiltrating macrophages have a strong impact on cancer progression and this has led to the suggestion that therapeutic targeting of these cells could form the basis of a powerful new type of cancer treatment. However, there is a strong need for increased understanding of the function of these tumor-associated macrophages in order to optimize the development of such new therapy. Most importantly, different subtypes of macrophages exist, but how these subtypes affect cancer progression and whether they contribute to the cancer-associated extracellular matrix degradation is very incompletely understood. In this proposed project I aim to elucidate the exact role of different subtypes of macrophages for cancer progression and for the accompanying extracellular matrix degradation. By using several experimental state-of-the-art techniques, I will directly examine the effect of different subtypes of macrophages on cancer growth and invasion. These techniques include two-photon microscopy, flow cytometry based cell sorting, next-generation sequencing, cell biology assays, and mouse genetic engineering. In particular, I am currently developing transgenic mice that allow both the visualization of specific macrophage subsets using fluorescence microscopy and the specific depletion of these cell populations. When combined with tumor models, these mice will provide unique insight about the importance of the cell types in question. The study will add significantly to our knowledge about macrophages in cancer biology and aid in the development of new cancer therapy strategies.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores