Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FOLOME

Financiado

Role of tissue-resident FOLR2+ Macrophages as Organizers of the Tumor Immune Mic...

Role of tissue-resident FOLR2+ Macrophages as Organizers of the Tumor Immune MicroEnvironment The infiltration of CD8+ T cells in tumors is crucial for the development of immunity against cancer. We have recently identified a tissue-resident macrophage population expressing the folate receptor 2 (FOLR2) and infiltrating hu... ver más

31/05/2028

INSERM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-17

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

INSERM

2.00M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

TLSaRNA Artificial induction of tertiary lymphoid structures (TLS) i... 181K€ Cerrado

MetaMacNiche Unravelling the cell-cell circuits underlying the functional... 176K€ Cerrado

REWIRE Rewire the lymph node niche to instruct T cell immunity 1M€ Cerrado

PID2020-116303RB-I00 NUEVOS ACTORES CON POTENCIAL PARA REGULAR LA DIFERENCIACION,... 333K€ Cerrado

SAF2014-54475-R MIGRACION, ACTIVACION Y DISFUNCION DE LINFOCITOS T EN CANCER 399K€ Cerrado

PID2021-122780OB-I00 CELULAS LINFOIDES INNATAS DE TIPO 3 COMO POSIBLES DIANAS PAR... 284K€ Cerrado

Duración del proyecto: 62 meses Fecha Inicio: 2023-03-17
Fecha Fin: 2028-05-31

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto The infiltration of CD8+ T cells in tumors is crucial for the development of immunity against cancer. We have recently identified a tissue-resident macrophage population expressing the folate receptor 2 (FOLR2) and infiltrating human and murine breast tumors. We have shown that tumor-infiltrating CD8+ T cell form lymphoid aggregate around FOLR2+ macrophages in a perivascular niche. The abundance of FOLR2+ macrophages associates with lymphocyte infiltration, the onset of tertiary lymphoid structures (TLS) and favorable prognosis. The abundance of TLS in cancer correlates with better prognosis and clinical response to immunotherapy. Yet, the molecular and cellular cues underlying TLS formation in tumors are ill understood. Here we hypothesize that FOLR2+ macrophages locally shape the compartment of tumor-infiltrating CD8+ T cells. Mechanistically, we will address if FOLR2+ macrophages spark local CD8+ T cell responses directly, by interacting with T lymphocytes or indirectly, by fostering TLS formation. To this end, we will (1) develop a high dimensional analysis of the FOLR2+ macrophage-perivascular niche using tissue imaging, spatial transcriptomic and single-cell RNA sequencing; (2) implement a new murine genetic model developed in the lab enabling the inducible ablation of FOLR2+ macrophages and conditional gene inactivation; (3) deliver a mechanistic analysis of cellular cross-talks involving FOLR2+ macrophages and supporting the development and maintenance of TLS. Lastly, we will explore new immunotherapy strategies harnessing the immunogenic function of FOLR2+ macrophages purposed to induce anti-tumor CD8+ T cell responses. To this end, we will use antibody-mediated targeting of FOLR2+ macrophages to increase antigen presentation and/or innate activation. This study will provide fundamental insights on how tissue-resident macrophages regulate tumor-immunity and a proof of concept for macrophage subset-specific therapeutic interventions to treat cancer.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores