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Let T Be

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Letting up senescence and inflammaging through T cells

With the increase in human life expectancy, there is an urgent need to understand the common molecular pathways by which aging results in a progressively higher susceptibility to chronic morbidity, disability, and frailty. In the... ver más

29/02/2028

CSIC

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-12-12

ERC-2021-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CSIC

2.00M€ | Lider

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Duración del proyecto: 62 meses Fecha Inicio: 2022-12-12
Fecha Fin: 2028-02-29

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto With the increase in human life expectancy, there is an urgent need to understand the common molecular pathways by which aging results in a progressively higher susceptibility to chronic morbidity, disability, and frailty. In the last years, immunometabolism has emerged as a new field to boost immune responses for cancer immunotherapies as well as to dampen autoimmune diseases. A recent discovery from my lab has revealed the critical role of T cell metabolism in accelerating the onset of age-associated diseases and multimorbidity. This finding has opened a new path to investigate the diverse T cell intrinsic and external stimuli that instruct T cell differentiation towards a dysfunctional state during aging, with the final goal of designing effective strategies to promote healthy aging. LetTBe will address the hypothesis that the time-dependent deterioration of T lymphocytes contributes not only to immunosenescence but also to the general aging process. The LetTBe project proposes to use multidisciplinary approaches to target age-associated T cells for preventing inflammaging, senescence and age-associated multimorbidity. Our central goals are: 1) To define age-associated T cells heterogeneity with special focus in their cellular origin, clonality, metabolic vulnerabilities and transcriptomic signatures; 2) To decode the environmental signals that are imprinted on age-associated T cells and contribute to their development; 3) To identify new strategies to targeting age-associated T cells for slowing down immunosenescence, and for boosting resilience to inflammaging, systemic senescence and age-related multimorbidity. In sum, LetTBe puts forward an ambitious but feasible program with the wide purpose of understanding the specific molecular mechanisms and metabolic requirements of age-associated T cells, with the final goal to guide new strategies to improve healthy aging.

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