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HEALING

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Cerrado

Joint training and research on Hedhehog Gli signalling and its pharmacological m...

Joint training and research on Hedhehog Gli signalling and its pharmacological modulation for regenerative medicine Debilitating degenerative diseases such as non-healing wounds and neurodegeneration do not yet have a cure. They represent a huge unmet medical need worldwide, especially in the aging European population. To reduce the incidence a... ver más

31/10/2013

UNIGE

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

UNIVERSITE DE GENEVE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 9 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2013-10-31 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

9 Participantes

UNIGE

0.00€ | Lider

N.D. | Participante

UNIROMA1

N.D. | Participante

FOUNDATION FOR RESEARCH AND...

N.D. | Participante

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Líder del proyecto

UNIVERSITE DE GENEVE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Debilitating degenerative diseases such as non-healing wounds and neurodegeneration do not yet have a cure. They represent a huge unmet medical need worldwide, especially in the aging European population. To reduce the incidence and improve recovery from such ephitelial diseases there is an major need to understand molecular signaling in order to promote stem cell behavior and enhance regeneration and healing. The key objectives of the HEALING network are 1) to train researchers in the fields of molecular signaling, developmental genetics, stem cell biology and small molecule chemistry; 2) to elucidate the mechanisms regulating one of the most promising pathways, Hedgehog-Gli (Hh-Gli) signaling; 3) to manipulate it by the development of specific small molecule agonists for future therapeutic use. Specifically, our research will (a) analyze the basic molecular mechanisms of Hh-Gli signaling in two model organisms and in human cells using leading technologies. In particular, (b) address the mechanisms that ensure controlled Hh-Gli function during skin wound healing and brain repair. (c) develop new small molecule Hh-Gli agonists for use as tools to be used as future therapeutics to enhance wound healing, regeneration and repair in a controlled manner. This network consists of 7 leading academic and research institutions, and 2 biotech companies from 8 European countries. It strengthens existing scientific collaboration, provides complementary expertise and brings together a critical mass for training and research. Additionally, it includes experts from Europe, Canada and Singapore, notably a pioneer in Hh-Gli signaling. HEALING will greatly enhance the training of the next generation of leading scientists in Hh-Gli signaling, stem cells and regenerative medicine. Thus, it will increase the competitiveness of highly skilled staff and of the European biotech industry, which has just recently discovered the role of Hh-Gli signaling in human disease and lags behind the US

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