Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FringEHE

Financiado

Cerrado

Uncovering the Role of Notch Modifiers in the Generation of Hematopoietic Stem C...

Uncovering the Role of Notch Modifiers in the Generation of Hematopoietic Stem Cells in the Embryo Hematopoietic Stem Cell (HSC)-based therapies are becoming a great expectation for the cure of several disorders that require HSCs for treatment. However, the incapacity to generate and maintain fully potent transplantable HSCs in... ver más

30/04/2014

Fundació Institut...

169K€

Presupuesto del proyecto: 169K€

Líder del proyecto

Fundació Institut Hospital del Mar D'Investig... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 16M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-04-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

Fundació Institut Hospital d...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

SAF2010-15450 DETERMINACION DEL DESTINO HEMATOPOYETICO EN EL EMBRION DE RA... 311K€ Cerrado

SAF2016-75613-R ESPECIFICACION DE CELULA MADRE HEMATOPOYETICA Y LEUCEMICA 436K€ Cerrado

HSCORIGIN From mesoderm to hematopoietic stem cell commitment cellula... 2M€ Cerrado

SAF2015-64287-R CONTROL MOLECULAR DE LAS CELULAS MADRE HEMATOPOYETICAS POR L... 206K€ Cerrado

FUN-HSC TACKLING FUNCTIONAL MATURATION FOR TRANSPLANTABLE HEMATOPOIE... 2M€ Cerrado

SAF2013-43072-R PAPEL DE GATA2 EN LA HEMATOPOYESIS EMBRIONARIA Y ESPECIFICAC... 109K€ Cerrado

Líder del proyecto

Fundació Institut Hospital del Mar D'Investig... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 16M€

Presupuesto del proyecto 169K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Hematopoietic Stem Cell (HSC)-based therapies are becoming a great expectation for the cure of several disorders that require HSCs for treatment. However, the incapacity to generate and maintain fully potent transplantable HSCs in vitro is still nowadays one of the main limitations for their wide application in cellular therapies. The study of the molecular mechanisms underlying HSC ontogeny in embryos is thus of crucial importance in order to elucidate the genetic networks that control the emergence and expansion of these cells. HSCs are first and possibly entirely formed in arterial-endothelium during embryonic life, a process dependent on Notch-signalling. However, the molecular events regulating these signals are mainly unknown. Fringe-glycosyltransferases are Notch modifiers contributing to the differential response of Notch to distinct ligands. It is hypothesized that the cross-talk between Notch and its cognate ligands in the arterial endothelium compartment is primarily a consequence of Fringe-mediated modification and the driving-force towards endothelium-HSC transition. This project aims the elucidation of the role Fringe as modulators of Notch-signalling towards specification of HSC identity at mid-gestation mouse embryos, an issue that has not been addressed so far. This work will be initiated with the identification of the Fringe involved on HSC emergence and with the study on how the modulation of their expression is correlated with Notch-ligand responsiveness and formation of hematopoietic precursors in vitro. The results obtained in this part of the project will be the basis of further in vivo experiments, using Fringe knock-in and knock-out animal models. The execution of this proposal should provide relevant clues on important biological questions involving stemness and cell differentiation. Moreover, it will pave the way for the development of new and more robust strategies to produce and expand HSCs a crucial issue for regenerative medicine.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores