Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

DEXTSTIM

Financiado

Investigating manual dexterity in healthy people and patients after stroke using...

Investigating manual dexterity in healthy people and patients after stroke using multi-locus transcranial magnetic stimulation Upper limb dexterity is a unique human ability commonly compromised by stroke. I suggest that the upper limb dexterity after stroke may be compromised as a result of dysfunctional inhibition of the nearby muscles. In patients with... ver más

31/08/2025

AALTO

216K€

Presupuesto del proyecto: 216K€

Líder del proyecto

AALTO KORKEAKOULUSAATIO SR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-07-04

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021

I+D

Cerrada hace 3 años

0% 100% 100%

2 Participantes

AALTO

215.53K€ | Lider

MPG

N.D. | Participante

Proyectos interesantes

EQC2018-004728-P Evaluación sistemática de la excitabilidad cortical y de la... 151K€ Cerrado

PSI2008-03175 LA REPRESENTACION DEL PROCESAMIENTO TEMPORAL EN LA PERCEPCIO... 127K€ Cerrado

DPI2015-68664-C4-2-R TECNICAS AVANZADAS DE NEUROIMAGEN POR RM PARA LA EVALUACION... 194K€ Cerrado

IJC2018-036189-I Neuromodulating the CNS for recovery of upper extremity moto... 93K€ Cerrado

INcEPTION Induction of NEuromuscular Plasticity for natural motor reha... 2M€ Cerrado

PSI2015-66277-R ESTIMULACION DEL LENGUAJE DE ACCION EN EL SISTEMA MOTOR. UN... 97K€ Cerrado

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 37 meses Fecha Inicio: 2022-07-04
Fecha Fin: 2025-08-31

Líder del proyecto

AALTO KORKEAKOULUSAATIO SR

TRL 4-5

Presupuesto del proyecto 216K€

Descripción del proyecto Upper limb dexterity is a unique human ability commonly compromised by stroke. I suggest that the upper limb dexterity after stroke may be compromised as a result of dysfunctional inhibition of the nearby muscles. In patients with mild motor impairment, this results in a lack of independent finger movements. In moderately-to-severely affected patients, the pathological synergies pose a major problem, affecting both proximal and distal joint movements. I will develop methods for evaluating the neural origins of the upper limb dexterity and its recovery after stroke, and for improving compromised motor control by transcranial magnetic stimulation (TMS) combined with electroencephalography, electromyography, and structural magnetic resonance imaging. I will perform multi-muscle cortical mapping using a novel neuromodulation technology, namely multi-locus TMS (mTMS), which allows stimulation of the nearby cortical targets with millisecond-scale delays between the pulses without moving the stimulator. This unique feature of mTMS will enable us to determine local excitation/inhibition (E/I) interactions among the cortical representations of different upper limb muscles. I will evaluate whether abnormal control of independent finger movements can be structurally and functionally explained in terms of the local E/I balance at the motor cortex. Then, I will utilize this information to develop unprecedented mTMS protocols that take into account the individual organization of the motor cortex and the possibility of its selective neuromodulation. In summary, I aim to demonstrate that (1) the intricate patterns of local E/I balance at the motor cortex are involved in the orchestration of muscle synergies, (2) the malfunctioning of this complex circuitry after stroke can lead to abnormal muscle-specific corticospinal excitability and impaired upper limb motor function, and (3) the local E/I balance can be manipulated with physiologically tuned multi-site mTMS protocols.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores