Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

IRENE

Financiado

Cerrado

In silico Rational Engineering of Novel Enzymes

IRENE project aims at overcoming existing bottlenecks for a broader diffusion of biocatalysis and at accelerating the sustainable innovation of chemical industry by developing computational methods and strategies that will enable... ver más

31/03/2012

UNITS

5M€

Presupuesto del proyecto: 5M€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI TRIESTE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 7 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2012-03-31 No tenemos la información de la convocatoria

0% 39% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

7 Participantes

UNITS

0.00€ | Lider

TU Delft

N.D. | Participante

UCPH

N.D. | Participante

PNPI

N.D. | Participante

Proyectos interesantes

CTQ2013-48287-R

Chemical Engine...

Data Science

159K€ Cerrado

NetMoDEzyme

Chemical Engine...

Data Science

1M€ Cerrado

RADICALZ

Chemical Engine...

Data Science

6M€ Cerrado

RYC2020-028628-I

Chemical Engine...

Data Science

324K€ Cerrado

CTQ2016-75752-R

Biotechnology

Chemical Engine...

105K€ Cerrado

RED2018-102403-T

Chemical Engine...

Biotechnology

6K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

UNIVERSITA DEGLI STUDI DI TRIESTE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 5M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto IRENE project aims at overcoming existing bottlenecks for a broader diffusion of biocatalysis and at accelerating the sustainable innovation of chemical industry by developing computational methods and strategies that will enable to rationally design and produce the next generation of biocatalysts for industrial applications. The consortium is funded on the combination of robust multidisciplinary expertise from EU, Russia and Uzbekistan. Due to the interaction between theoretical groups and experimentalists all computational tools used in this project will be validated by experiments. Failures and successes will be used for methods’ evaluation and tuning, in an iterative process that will lead to new methods but also to the definition of practical guidelines, for any specific enzyme design issue. The convergence of different expertise will face 4 main tasks: 1) fast rational design of efficient biocatalysts; 2) fast and efficient in silico screening of available enzymes/mutants to exploit catalytic potential of existing biocatalyst and providing quantitative parameters describing enzyme’s efficiency; 3) fast substrate-screening and rational substrate engineering; 4) understanding molecular basis of biocatalyst’ action and properties. IRENE will pursue these objectives by taking advantage of computational strategies used in different disciplines and integrate them in an unified concept for studying enzyme catalysis. The four main families of computational methods, Quantum Mechanics, Molecular Mechanics, Quantitative Structure Activity Relationships and Bioinformatics, will used in an integrated approach. The project will have three major design subjects: 1) introduction of new activities in specific enzyme scaffolds (reaction promiscuity); 2) improvement of catalytic activity towards specific targets (substrate promiscuity); 3) the redesign of enantioselectivity. For each subject the work will focus on different specific enzymatic activities of industrial relevance.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores