GRADIENT
Financiado
Impact of gut microbiota targeted dietary intervention on obesity: A precision...
Impact of gut microbiota targeted dietary intervention on obesity: A precision medicine approach
The main objective is to analyze the impact of dietary hypocaloric interventions based on their capacity to generate ketone bodies in different degrees of intensity: using Intermittent fasting, KetoDiet in comparison with the clas...
The main objective is to analyze the impact of dietary hypocaloric interventions based on their capacity to generate ketone bodies in different degrees of intensity: using Intermittent fasting, KetoDiet in comparison with the classical MedDiet, in individuals with obesity, and their influences on the gut microbiota, resistome, host metabolism, and the possible genetic and epigenetics links. We aim to contribute with the advance in the development of a precision medicine approach in obesity to decrease the prevalence of obesity and its associated comorbidities, and to evaluate the impact of dietary interventions as an alternative approach to antimicrobial resistance.
To achieve our goal, we will study in a randomized cross-over group of individuals with obesity: A) Analyse the effect of dietary interventions (MedDiet, intermittent fasting (IF) and KetoDiet) on the gut microbiota composition and the relationship with anthropometrics, metabolic, inflammatory and epigenetics driven factors at short term (1 month) B) Analyse the effect of dietary interventions (MedDiet, IF, KetoDiet) on the gut microbiota composition and the relationship with epigenetics factors at medium-term(3 months) C) Evaluate the impact of the gut microbiota targeted dietary interventions (MedDiet, IF and KetoDiet) at short- and medium-term on the gut resistome and relate it with the inflammatory milieu of the host.
Our results will help to improve the treatment of metabolic diseases associated to obesity using a precision medicine approach based on the influence of diet interventions on the gut microbiota, gut resistome, host response and environmental factors. The outcome of this project will have an impact in the health sector by improving mental health and physical health of all overweight and obese individuals, in the economy sector by reducing the need of surgical approaches to achieve weight loss, reducing the risk of development obesity-related complications and overuse of antimicrobials.
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Duración del proyecto: 31 meses
Fecha Inicio: 2024-05-15
Fecha Fin: 2027-01-05
Fecha Fin: 2027-01-05
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-05-15
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2023-PF-01-01:
MSCA Postdoctoral Fellowships 2023
Cerrada
hace 1 año
Presupuesto
El presupuesto total del proyecto asciende a
181K€
Líder del proyecto
FUNDACIÓN INSTITUTO MEDITERRÁNEO PARA EL AVAN...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
6M
Perfil tecnológico
TRL
4-5
6M