Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

BrainGate

Financiado

Illuminating body-brain communication channels at the choroid plexus and their i...

Illuminating body-brain communication channels at the choroid plexus and their impact on brain physiology. In contrast to other organs, the brain is surrounded by a system of specialized anatomical barriers isolating it from direct contact with immune cells and microbial products present in the blood. However, such factors do dynamical... ver más

31/03/2028

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-21

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2022-STG: ERC STARTING GRANTS

I+D

Cerrada hace 2 años

0% 100% 100%

1 Participantes

1.50M€ | Lider

Proyectos interesantes

PID2020-115961RB-C32 ANALISIS NUMERICO E INTEGRAL DEL FLUJO DEL LIQUIDO CEFALORAQ... 127K€ Cerrado

MRStain Non-invasive staining of tissue microstructure in temporal l... 2M€ Cerrado

RTI2018-097038-B-C22 PLATAFORMAS MICROFISIOLOGICAS IN VITRO PARA LA MIMETIZACION... 70K€ Cerrado

PID2020-113894RB-I00 EL CEREBRO EXTRACELULAR: COMO LA ESTRUCTURA Y LA DINAMICA DE... 224K€ Cerrado

RED2018-102323-T RED DE INVESTIGACION SOBRE COMUNICACION NEURONAL PATOLOGICA... 20K€ Cerrado

PID2020-115961RB-C31 ESTUDIO EXPERIMENTAL DEL FLUJO DE LIQUIDO CEFALORRAQUIDEO EN... 169K€ Cerrado

Últimas noticias

30-11-2024: Cataluña Gestión For... Se ha cerrado la línea de ayuda pública: Gestión Forestal Sostenible para Inversiones Forestales Productivas para el organismo:

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

Duración del proyecto: 60 meses Fecha Inicio: 2023-03-21
Fecha Fin: 2028-03-31

Líder del proyecto

INSTITUT PASTEUR

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto In contrast to other organs, the brain is surrounded by a system of specialized anatomical barriers isolating it from direct contact with immune cells and microbial products present in the blood. However, such factors do dynamically shape brain function in homeostasis and disease. Because of this unusual anatomy, the pathways of blood-brain communication are still poorly understood, while this understanding would provide a fundamental insight into brain function regulation, and enrich the current knowledge of neurological disease mechanisms. My previous work suggests that the choroid plexus (CP) is a central player mediating the influence of immune and microbial signals on the brain. The CP epithelium is a monolayer barrier tissue, which on the side facing the blood has the ability to sense such peripheral factors, and on the side facing the brain, produces the cerebrospinal fluid (CSF)–a liquid carrying nutrients and signaling molecules, which contacts nearly all brain cells, and ensures brain homeostasis. I therefore hypothesize that peripheral immune and microbial factors may shape brain function indirectly, via regulation of the CSF properties at the CP epithelium. Based on our preliminary data, and building on my past expertise in CP biology, neuroscience and immunogenomics, here I propose an interdisciplinary project BrainGate, striving to illuminate the physiological mechanisms and roles of gut-blood-CP-brain communication axis during post-natal development (Aim 1), under conditions of microbiota perturbation (Aim 2) and along the circadian cycles (Aim 3). By developing new tools for CP-specific genetic perturbation and combining them with approaches of spatial transcriptomics and behavioral readouts in mouse models, this project will reveal fundamental principles of physiological regulation of brain development, function and maintenance and pave the way for future investigation of the gut-blood-CP-brain communication circuit in neurological disease.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores