Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ANCOM

Financiado

Design of artificial organelles to modulate the astrocyte-neuron communication

The brain is supplied by a complex and vast vascular network whose interactions are difficult to grasp in their entirety. The neurovascular unit (NVU) was thus introduced and represents the minimal functional unit linking the brai... ver más

30/04/2026

215K€

Presupuesto del proyecto: 215K€

Líder del proyecto

AARHUS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-03

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

I+D

Cerrada hace 1 año

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

214.93K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

TEC2015-70104-P PLATAFORMA MICROFLUIDICA 3D DE CULTIVO NEURONAL COMPARTIMENT... 179K€ Cerrado

PDC2022-133918-C21 MONITORIZACION Y FLUIDICA INTEGRADA EN CHIP DE CO-CULTIVO NE... 102K€ Cerrado

RTI2018-097038-B-C22 PLATAFORMAS MICROFISIOLOGICAS IN VITRO PARA LA MIMETIZACION... 70K€ Cerrado

BES-2014-067594 COMUNICACION ASTROCITO-INTERNEURONA Y EL PROCESAMIENTO DE IN... 88K€ Cerrado

RTI2018-097038-B-C21 SISTEMA MICROFISIOLOGICO PARA MIMETIZAR LAS BARRERAS HEMATO-... 110K€ Cerrado

RYC2018-026293-I ASTROCYTE RHYTMHYC REGULATION OF BRAIN FUNCTION 309K€ Cerrado

Duración del proyecto: 24 meses Fecha Inicio: 2024-04-03
Fecha Fin: 2026-04-30

Líder del proyecto

AARHUS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 215K€

Descripción del proyecto The brain is supplied by a complex and vast vascular network whose interactions are difficult to grasp in their entirety. The neurovascular unit (NVU) was thus introduced and represents the minimal functional unit linking the brain and its vessels. NVU cells interact closely to maintain the integrity of the blood-brain barrier and supply the brain with nutrients. Among these, astrocytes play the key role of mediator between the endothelial cells, supporting the blood flow, and the neurons. The astrocyte-neuron lactate shuttle is an essential communication pathway, and its control is crucial for brain homeostasis and thus brain health. The research hypothesis of ANCOM is that the engineering of astrocytes will allow to modulate their communication with neurons in close proximity, cultured in a paper-based NVU model. Engineered astrocytes can thereby be used to influence neurons’ behaviour and thus contribute to tune the brain’s activity. Specifically, artificial organelles will be designed to boost the lactate production in the astrocytes. These will be made of silica nanoparticles with lactate dehydrogenase enzyme immobilised on their surface and placed in the cytosol of the astrocytes. Upon a boosted lactate release, a beneficial effect on neurons is predicted either in simple cell cocultures but also in more complex systems. For that purpose, a dynamic in vitro paper-based model of the NVU containing endothelial cells, pericytes, astrocytes and neurons will be established. Moreover, by employing a new approach developed by the Städler lab, it will even be possible to add active locomotion to these artificial organelles with the aim of targeting the astrocytes through the blood circulation. ANCOM aims thus at offering an easily accessible NVU model, able to address many questions in neuroscience, contributing to the development of brain therapies. This interdisciplinary project will allow me to broaden my skills and start my career as an independent researcher.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores