Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

HYPMET

Financiado

Hyperpolarized Magnetic Resonance at the point-of-care

HYPMET proposes a pioneering research methodology for hyperpolarized magnetic resonance for real-time monitoring of upregulated metabolic pathways in cancer cells and in-vivo and for body fluid metabolic analyses with the prospect... ver más

30/04/2029

UNIPD

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI PADOVA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-10-26

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100%

1 Participantes

UNIPD

1.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

EQC2019-006485-P RENOVACIÓN PLATAFORMA IMAGEN MOLECULAR MS-IMAGING DE LA UNID... 592K€ Cerrado

PID2021-124171OB-I00 USO DE LA RMN DE 31P PARA EL ANALISIS METABOLOMICO DE TEJIDO... 224K€ Cerrado

CTQ2009-07430 DESARROLLO DE PLATAFORMAS ANALITICAS EN METABOLOMICA PARA LA... 152K€ Cerrado

PID2021-126543OB-C22 PROCESADO DE SEÑAL EN METABOLOMICA CUANTITATIVA DIRIGIDA Y D... 182K€ Cerrado

MITI Non-ionizing Metabolic Imaging for predicting the effect of... 2M€ Cerrado

RESPONSE Early detection of treatment response in breast cancer 2M€ Cerrado

Duración del proyecto: 66 meses Fecha Inicio: 2023-10-26
Fecha Fin: 2029-04-30

Líder del proyecto

UNIVERSITA DEGLI STUDI DI PADOVA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto HYPMET proposes a pioneering research methodology for hyperpolarized magnetic resonance for real-time monitoring of upregulated metabolic pathways in cancer cells and in-vivo and for body fluid metabolic analyses with the prospect of revolutionizing the medical approach to personalised treatments. A common analytical method for structural biology, medical imaging, and chemical analysis is nuclear magnetic resonance (NMR), which is flexible but intrinsically insensitive. Even in the most sensitive NMR spectra, many endogenous compounds found in blood, saliva, or urine are currently unresolved. HYPMET will establish a ground-breaking technology enabling the detection of body fluids metabolites below the current limit of NMR detection (~μM) and the real-time monitoring of clinically relevant metabolic pathways in-cells and in-vivo; it will enable NMR metabolomics analyses at the point-of-care and will be fully compatible with personalised medical treatments; it will be compact (less than 10×10×30 cm) and will not require superconducting magnets. Emerging methods (e.g. hyperpolarisation methods - HM) can boost the NMR signal intensity. HYPMET will merge two HMs to achieve NMR signal enhancements of several thousand-fold continuously, in the liquid state and at ultra-low-magnetic field (ULF, i.e. <10 mT) for many nuclear isotopes. The two HMs are: Overhauser Dynamic Nuclear Polarization (ODNP) and Signal Amplification By Reversible Exchange (SABRE). The PI unique expertise spans method development on various HMs and development and implementation of a protocol for real-time monitoring of pyruvate to lactate conversions in-cells and in-vivo to probe the state of a tumor in real-time. Success in this multidisciplinary project will pave the way for efficient NMR metabolomics analyses and for better real-time metabolic conversion monitoring directly at the point-of-care. In the future, the technology could be further reduced in size and become a widespread clinical tool.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores