Innovating Works

NICI

Financiado
Non Invasive Chemistry Imaging in the whole human body
The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resona... The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body. Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment. Breakthroughs: I. Methodology for the discovery of discriminative biomarkers and II. Technological platform for full body biochemical imaging. Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding. Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging. High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging. Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians. The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its predictive and prognostic value by researching a stratification strategy for patients with liver metastasis of gastrointestinal cancer. (This is one out of many possible applications.) ver más
31/08/2023
UMC UTRECHT
3M€
Duración del proyecto: 63 meses Fecha Inicio: 2018-05-24
Fecha Fin: 2023-08-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2023-08-31
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
FETOPEN-01-2016-2017: FET-Open research and innovation actions
Cerrada hace 8 años
Presupuesto El presupuesto total del proyecto asciende a 3M€
Líder del proyecto
UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5