SPARK
Financiado
Human Stem cell-based technologies to model PARKinson’s disease and drive patien...
Human Stem cell-based technologies to model PARKinson’s disease and drive patient-specific cell therapy
Loss of dopaminergic (DA) neurons in midbrain underlies motor dysfunction in Parkinson´s disease (PD). PD is one of the most challenging neurodegenerative diseases to study due to the limitations of existing model systems in recap...
Loss of dopaminergic (DA) neurons in midbrain underlies motor dysfunction in Parkinson´s disease (PD). PD is one of the most challenging neurodegenerative diseases to study due to the limitations of existing model systems in recapitulating its complex etiology resulting from individual risk variants, distinct genetic and epigenetic backgrounds, and age-related environmental triggers. The SPARK project (Human Stem cell-based technologies to model PARKinson´s disease and drive patient-specific cell therapy) will use induced pluripotent stem cells reprogrammed from PD patient-derived somatic cells as well as from age- and sex-matched healthy individuals to model key aspects of DA neurodegeneration. Advanced human stem cell-based technologies including brain organoids and cell transplantation will be exploited to recreate functionally mature human DA tissue in an ad hoc disease-like environment. A single-cell sequencing approach will be used to obtain molecular insights into PD etiopathogenesis and the pathological mechanisms responsible for DA neuron degeneration. Lastly, gene editing in a patient-specific genetic background will be performed to create an autologous source of healthy DA neurons reverted from the disease-related phenotype. These cells will be pre-clinically validated in a PD rat model, with a view to ultimately achieving autologous cell replacement treatments for PD.
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Duración del proyecto: 33 meses
Fecha Inicio: 2022-06-07
Fecha Fin: 2025-04-02
Fecha Fin: 2025-04-02
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-07
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2021-PF-01-01:
MSCA Postdoctoral Fellowships 2021
Cerrada
hace 3 años
Presupuesto
El presupuesto total del proyecto asciende a
189K€
Líder del proyecto
CONSIGLIO NAZIONALE DELLE RICERCHE
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
N.D. |
Participante