Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

HEM_ID

Financiado

Cerrado

HEMatopoietic cell IDentity genetic and epigenetic regulation in normal and ma...

HEMatopoietic cell IDentity genetic and epigenetic regulation in normal and malignant hematopoiesis In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and... ver más

31/10/2015

UNIMIB

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI MILANOBICOCCA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 12 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-10-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

12 Participantes

UNIMIB

0.00€ | Lider

CNRS

N.D. | Participante

UNIROMA1

N.D. | Participante

CEMM FORSCHUNGSZENTRUM FUER...

N.D. | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

JCI-2009-04533 MECANISMOS EPIGENÉTICOS IMPLICADOS EN EL CONTROL DE PROCESOS... 101K€ Cerrado

SAF2014-52009-R IDENTIFICACION DE MECANISMOS MOLECULARES INVOLUCRADOS EN LA... Cerrado

PRELEUKMEC Deciphering the intrinsic and extrinsic mechanisms shaping a... 201K€ Cerrado

SuccHSC Succinate induced leukemic stem cell formation via epigeneti... 202K€ Cerrado

TFs-HSCs The identification of the Combinatorial Transcription Factor... 212K€ Cerrado

SAF2014-58228-R MECANISMOS DE REPRESION TRANSCRIPCIONAL EN LA LINFOPOYESIS N... 182K€ Cerrado

Líder del proyecto

UNIVERSITA DEGLI STUDI DI MILANOBICOCCA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been well defined in the last years, the precise molecular circuits governing the balance between proliferation/commitment/specification and how these are corrupted in disease are largely unknown. The focus of Hem-ID is a highly integrated approach to study the functional interactions between the genetic regulatory circuits orchestrated by transcription factors –TFs-, (that direct the progressive cell type specification) and epigenetic mechanisms (that establish the cellular memory that fixes cell fate decisions during differentiation) in physiological hematopoiesis and in leukemia with the final goal of formulating novel diagnostic/prognostic markers and therapeutic approaches in treating leukemias. HEM_ID will: -Decipher Modular Networks assembled by master TFs controlling hematopoietic self renewal and differentiation and the molecular dynamics of TFs/DNA interactions by unique biophysical approache -Identify epigenetic modifiers (new relevant loci, -epiQTLs, DNAmethylation, Polycomb dependent-gene silencing, miRNA and long non coding RNAs) involved in the pathogenesis of leukemias. The strength of Hem-ID ITN lies in the high quality multidisciplinary -but strictly integrated- expertise and technological platforms covering the complete pathway from basic research to its clinical exploitation- contributed from both public Institutions and Private sector and made available to Hem-ID Fellows. Besides research, an integrated training program of scientific and complementary activities will be offered to HEM-ID Fellows that will complement and strengthen their career development.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores