Triterpenes are one of the most diverse groups of plant natural products, with important roles in plant defense and wide use in medicine, food, and cosmetics. So far, studies on triterpene biosynthesis have largely focused on eudi...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
BIO2016-77216-R
EVOLUCION Y CONSERVACION FUNCIONAL DE LA RUTA DE SEÑALIZACIO...
375K€
Cerrado
PID2021-126472OB-I00
METABOLITOS SECUNDARIOS EN BRASSICACEAE: IMPLICACIONES EN LA...
266K€
Cerrado
AGL2009-13431-C02-02
INCREMENTO EN LOS NIVELES DE PRODUCCION DE TERPENOS Y PIRONA...
85K€
Cerrado
AGL2012-35539
GENETICA Y MEJORA DE BRASICAS HORTICOLAS: PAPEL DE LOS METAB...
234K€
Cerrado
MultiPly
FMO1 Multifunctionality for improved Plant health
231K€
Cerrado
RTI2018-096591-B-I00
METABOLITOS SECUNDARIOS EN BRASSICACEAE: IMPLICACIONES EN LA...
212K€
Cerrado
Información proyecto EXTRIDIM
Duración del proyecto: 37 meses
Fecha Inicio: 2019-07-15
Fecha Fin: 2022-08-31
Líder del proyecto
JOHN INNES CENTRE
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
225K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Triterpenes are one of the most diverse groups of plant natural products, with important roles in plant defense and wide use in medicine, food, and cosmetics. So far, studies on triterpene biosynthesis have largely focused on eudicot plants, while little is known about triterpene biosynthesis in monocots. Here, we seek to expand current knowledge of triterpene chemistry and biochemistry in monocots and to investigate mechanisms of metabolic diversification in this group of plants, and specifically in the cereals group, which together provides more than half of the global human caloric intake. Monocot genomes will be mined for identification of new triterpene-related genes and biosynthetic gene clusters. These will be utilized for biosynthesis of novel triterpene compounds via combinatorial recombinant expression in yeast and plant systems. Entire triterpene metabolic pathways will ultimately be introduced into the monocot model plant Brachypodium distachyon, and pathogen-tolerance of the engineered plants will be evaluated. This will serve as an important proof-of-concept for the possibility of introducing these pathways into agriculturally-important cereals and grasses. The recent publication of the common wheat genome, coupled with fears for re-emergence of devastating fungal wheat pathogens in Europe, indicate the timeliness and relevance of the proposed action. EXTRIDIM is a highly interdisciplinary project that will draw upon the synergistic combination of the expertise and well-established scientific approach of the host lab, together with the background and complementary skills of the researcher in plant molecular biology and metabolic engineering. The proposed research will greatly contribute to the researcher’s career development and strengthen the host lab, will advance our understanding of triterpene biosynthesis in the agriculturally-important cereal crops, and will potentially lead to new applications in plant protection and drug discovery.