Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

EEPPIBM

Financiado

Cerrado

Exploring the evolution of protein protein interactions and their networks using...

Exploring the evolution of protein protein interactions and their networks using biophysical models The evolution of protein interactions has produced interaction networks and much biological complexity. Although molecular phylogenetics reveals the end points of evolutionary searches, little is known about the trajectories of in... ver más

28/02/2015

BARCELONA SUPERCOM...

166K€

Presupuesto del proyecto: 166K€

Líder del proyecto

BARCELONA SUPERCOMPUTING CENTERCENTRO NACIONA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 118M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-02-28 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

BARCELONA SUPERCOMPUTING CEN...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PROTINT Towards a quantitative framework for understanding protein p... 1M€ Cerrado

MUTANOMICS Determining in vivo protein structures and understanding gen... 2M€ Cerrado

BIO2010-22324 DOCKING ENTRE PROTEINAS Y OTROS ASPECTOS: AVANCES EN LA DESC... 194K€ Cerrado

BES-2009-024653 INTEGRACION, ANALISIS Y MODELADO DE REDES DE RUTAS BIOLOGICA... 43K€ Cerrado

BES-2011-045634 DOCKING ENTRE PROTEINAS Y OTROS ASPECTOS: AVANCES EN LA DESC... 43K€ Cerrado

MTM2012-38067-C02-02 METODOS PARA LA IDENTIFICACION DE INTERACCIONES Y PERFILES G... 21K€ Cerrado

Líder del proyecto

BARCELONA SUPERCOMPUTING CENTERCENTRO NACIONA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 118M€

Presupuesto del proyecto 166K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The evolution of protein interactions has produced interaction networks and much biological complexity. Although molecular phylogenetics reveals the end points of evolutionary searches, little is known about the trajectories of interacting proteins through sequence space over evolutionary time. A major bottleneck is the inability to extensively map how binding affinity changes with sequence. A previously developed affinity prediction model will be modified to predict affinity changes upon mutation. Preliminary results show that this method has unprecedented speed and accuracy. In the proposed research, the preliminary models will be improved and thoroughly validated. Subsequently, they shall be used to assess millions of combinations of interface mutations in structurally annotated interaction networks. The mutational robustness of interactions will be determined, compared with theoretical models, and its relationships with observed evolutionary rates investigated at the amino acid, interface, protein and network levels. Then, paths connecting orthologs to each other and to ancestral protein reconstructions will be determined and characterised. The positions on the phylogenetic trees where the affinity imbuing contacts are gained will be determined, as well as the positions where interactions are lost, revealing network rewiring. This will illuminate the changes in interactions over time, and show how interface biophysics constrains the functionally viable paths available for interaction evolution. The relationships between extent of constraint, evolutionary rates and network properties will be investigated. We hypothesise that the inherent ability to form interactions and modulate specificity can explain a number of observations garnered from network evolution studies. Finally, the human-virus exogenous interaction network will be investigated, potentially revealing strategies and counterstrategies employed as viruses vie to hijack regulatory mechanisms.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores