CyanoAsterisMETAB
Financiado
Exploration of the biosynthetic potential of the secondary metabolome of the new...
Exploration of the biosynthetic potential of the secondary metabolome of the newly identified fungal endophyte Cyanodermella asteris
In the proposed research I aim to explore the secondary metabolome of the newly identified fungal endophyte Cyanodermella asteris. In this regard, we have selected two in silico-predicted polyketide synthase gene clusters, which w...
In the proposed research I aim to explore the secondary metabolome of the newly identified fungal endophyte Cyanodermella asteris. In this regard, we have selected two in silico-predicted polyketide synthase gene clusters, which will be further examined. The selected gene clusters thereof are chosen for vector construction in Escherichia coli and subsequently the heterologous expression in fungal hosts (Aspergillus niger or Aspergillus nidulans) will be performed. Afterwards, the engineered expression strains will be examined in a combined effort applying mass spectrometry and nuclear magnetic resonance experiments to identify the newly produced compounds. Additional metabolomics-based tools and molecular networking will be employed. Moreover, the biosynthetic pathways of the isolated natural products of the respective gene clusters will be fully delineated.
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Duración del proyecto: 31 meses
Fecha Inicio: 2022-06-23
Fecha Fin: 2025-01-31
Fecha Fin: 2025-01-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-23
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2021-PF-01-01:
MSCA Postdoctoral Fellowships 2021
Cerrada
hace 3 años
Presupuesto
El presupuesto total del proyecto asciende a
174K€
Líder del proyecto
TECHNISCHE UNIVERSITAET DRESDEN
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5