Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FlexAggon

Financiado

Evolutionary origin of cell adhesion: the basis of multicellularity in the choan...

Evolutionary origin of cell adhesion: the basis of multicellularity in the choanoflagellate Choanoeca flexa How animal multicellularity evolved from unicellular ancestors remains an open evolutionary question. One key pre-requisite for the evolution of animal multicellularity was the evolution of cell adhesion. However, little is known... ver más

30/04/2025

196K€

Presupuesto del proyecto: 196K€

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-23

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

195.91K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

EvoMorphoCell From cell shape to organism shape: the cellular basis for th... 1M€ Cerrado

PID2020-120609GB-I00 EL ORIGEN DE LOS ANIMALES; UNA APROXIMACION FUNCIONAL Y DE B... 351K€ Cerrado

BFU2008-00227 INVESTIGACIONES CITOLOGICAS Y MOLECULARES EN ESTADOS EVOLUTI... 103K€ Cerrado

BFU2017-90114-P ORIGEN DE ANIMALES: DESCIFRANDO LA NATURALEZA DEL ANCESTRO U... 305K€ Cerrado

BFU2014-57779-P ORIGEN, DIVERSIFICACION Y DIVERSIDAD DE METAZOOS, HONGOS Y S... 484K€ Cerrado

BFU2011-23434 EL ORIGEN DEL REINO ANIMAL: UN ANALISIS GENOMICO, FILOGENOMI... 323K€ Cerrado

Duración del proyecto: 25 meses Fecha Inicio: 2023-03-23
Fecha Fin: 2025-04-30

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 196K€

Descripción del proyecto How animal multicellularity evolved from unicellular ancestors remains an open evolutionary question. One key pre-requisite for the evolution of animal multicellularity was the evolution of cell adhesion. However, little is known about how cell adhesion evolved in the animal stem. In the last decades, considerable advances to reconstruct early animal evolution have come from investigations of the closest living unicellular relatives of animals, notably the choanoflagellates. These microeukaryotes have become powerful models to address the evolution of animals, for several reasons: (1) they are the sister group to all animals; (2) their genomes encode homologs of genes that can inform about animal origins, including an animal-like cell-adhesion toolkit; (3) they can temporarily adhere to each other and form multicellular colonies; and (4) they are amenable to functional genetics. Therefore, studies on choanoflagellate molecular and cell biology can inform the mechanisms of the emergence of multicellularity in animals. Here, I will investigate the cell adhesion mechanisms governing multicellularity in the recently discovered choanoflagellate Choanoeca flexa. C. flexa has direct cell-cell adhesion and aggregative multicellularity (unique in choanoflagellates) and also undergoes light-controlled collective contractility of colonies (unique in unicellular relatives of animals), making it a powerful model to study the emergence of collective behaviors. I will perform a systematic characterization of the environmental and endogenous factors regulating cell adhesion during colony formation in C. flexa using a combination of genetic engineering, biochemistry, proteomics, molecular and cell biology approaches, and functional genomics. The data generated here will contribute to converting C. flexa into an experimentally tractable species and has the potential to shed light on the pre-metazoan function of cell adhesion genes.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores