Evolution and development of pharyngeal pouches and pre oral gut in basal fishes
Vertebrates, which include our own species, are the most diverse and successful group of Deuterostomes. Success of this group has been explained by the evolution of elaborated head skeleton adapted to capturing and processing larg...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
BES-2014-068494
DINAMICA DEL EPIGENOMA Y DE LOS PAISAJES REGULADORES DURANTE...
88K€
Cerrado
TOOTHJAW
Evolution of jaws and teeth new insights into key innovati...
300K€
Cerrado
AMPHIREG
Development of the Cephalochordate amphioxus Branchiostoma...
152K€
Cerrado
PID2020-113497GB-I00
SOLIDEZ Y PLASTICIDAD REGULADORA DURANTE EL DESARROLLO Y LA...
212K€
Cerrado
PRE2018-085766
Genetic control of epithelial morphogenesis in vertebrates.
93K€
Cerrado
EEBB-I-12-04806
DESARROLLO Y EVOLUCION DEL PROSENCEFALO EN VERTEBRADOS PRE-A...
10K€
Cerrado
Información proyecto Pharynx2016
Duración del proyecto: 29 meses
Fecha Inicio: 2017-03-23
Fecha Fin: 2019-08-31
Líder del proyecto
UNIVERZITA KARLOVA
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
155K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Vertebrates, which include our own species, are the most diverse and successful group of Deuterostomes. Success of this group has been explained by the evolution of elaborated head skeleton adapted to capturing and processing large prey. Most of this skeleton derives from neural crest cells migrating into the pharynx during and after the formation of pharyngeal pouches. To better understand how development of these structures evolved, the research project will study representatives of three basal fish lineages that occupy key positions in jawed-vertebrate phylogeny. It will employ methods of genomics, gene expression, and gene manipulation including CRISPR/Cas9 gene editing system to test a mechanistic model of pouch formation and its relationships to pre-oral endoderm development. The proposal builds upon the Fellow’s research of jawed and jawless vertebrates and bridges a gap in our knowledge of the pharyngeal evolution between the jawed and jawless vertebrates and at the same time between vertebrates and their chordate and deuterostome ancestors. Two-way knowledge transfer is a crucial feature of this project: the Fellow will take advantage of the proficiency of the Supervisor and the Department in embryology, morphology, manipulation, and husbandry of the rare basal fishes and in the genomics and transcriptomics, while at the same time he will transfer his expertise in genetic regulation of development and CRISPR/Cas9 gene editing in non-model organisms to the Supervisor and Host Institution.