Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

EPIGENAIR

Financiado

Cerrado

EPIGENomic markers for AIR pollution induced health effects

Exposure to particulate matter (PM) has detrimental effects on the health outcomes. Recently is shown that particulate matter increases the risk for lung cancer at the population level, which is assessed within the framework of th... ver más

30/04/2016

IMPERIAL COLLEGE O...

231K€

Presupuesto del proyecto: 231K€

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-04-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IMPERIAL COLLEGE OF SCIENCE...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2020-116274RB-I00 ENFOQUE OMICO INTEGRADOR PARA EVALUAR EL PAPEL DE LA METILAC... 145K€ Cerrado

PredictCOPD Understanding the host environmental interactions across the... 2M€ Cerrado

SAF2012-32991 EPIGENETICA DE LA EXPOSICION TEMPRANA A CONTAMINACION ATMOSF... 105K€ Cerrado

PID2020-114787RB-I00 ASOCIACION ENTRE EL POTENCIAL OXIDATIVO LIGADO AL MATERIAL P... 127K€ Cerrado

PID2020-113812RB-C31 CONTAMINACION ATMOSFERICA Y SALUD MENTAL. ¿COMO INFLUYEN LOS... 125K€ Cerrado

JCI-2011-09479 Cancer, Childhood, Environmental exposure, Genetics, and Mol... 96K€ Cerrado

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 231K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Exposure to particulate matter (PM) has detrimental effects on the health outcomes. Recently is shown that particulate matter increases the risk for lung cancer at the population level, which is assessed within the framework of the European Study of Cohorts for Air Pollution Effects (ESCAPE). This study dramatically increased the epidemiological weight of this association, however mechanistic evidence at this level is mostly scarce. Epigenetics, the heritable changes in gene expression that do not involve a change in DNA sequences such as DNA methylation can modulate genomic functions under exogenous influence such as air pollution. So far, several lines of research suggest that the mechanisms involved are through inflammation and oxidative damage. In spite of the specific DNA methylation results a large genome-wide epigenetic analysis in relation to ambient air pollution has not been performed, as such this gap in knowledge will be addressed by this proposal. In this project I hypothesise that DNA methylation of inflammation and oxidative stress pathways are key in PM-induced effects. I aim to identify changes in methylation related to exposure to specific air pollutants by profiling full genome methylation data. For this project I will combine exposure and epigenetic data from three large prospective studies of over 1200 individuals from the ESCAPE (FP7), HuGeF (Human Genetics Foundation, Italy) and EnvironGenoMarkers (FP7) studies. I will explore the association of genome wide DNA methylation (Illumina 450K) with ambient air pollution in healthy subjects (n=1200) with detailed air pollution measurements, including personal estimates of PM2.5, PM10, PMcoarse, NO2, NOx and traffic indicators. I will perform a study of pathways and networks that PM exposure affects followed in depth cross-omics analysis between DNA methylation and transcriptomics data.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores