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PredictCOPD

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Understanding the host environmental interactions across the lifespan determinin...

Understanding the host environmental interactions across the lifespan determining lung function trajectories and COPD Chronic Obstructive Pulmonary Disease (COPD) has been traditionally understood as a self-inflicted disease caused by tobacco smoking occurring in old individuals. Over the past few years, however, our group and others have propose... ver más

30/11/2027

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSIDAD DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 326

Fecha límite participación Sin fecha límite de participación.

Ver 4 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-02

ERC-2021-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada

0% 100% 100%

Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

4 Participantes

869.13K€ | Lider

UNIVERSITAIR MEDISCH CENTRUM...

253.75K€ | Participante

FUNDACIO CLINIC PER A LA REC...

875.44K€ | Participante

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Duración del proyecto: 63 meses Fecha Inicio: 2022-08-02
Fecha Fin: 2027-11-30

Líder del proyecto

UNIVERSIDAD DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 326

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Chronic Obstructive Pulmonary Disease (COPD) has been traditionally understood as a self-inflicted disease caused by tobacco smoking occurring in old individuals. Over the past few years, however, our group and others have proposed that the pathogenesis of COPD goes beyond smoking, and that there is a range of lung function trajectories through life (trajectome); some of them have roots in early life and can lead to COPD, cardiovascular and metabolic morbidity as well as premature death, while others are associated with healthy ageing. Here I propose that, detrimental gene (G) and environment (E) interactions occurring early in life (T) constitute a ‘first injury hit’ that alters the normal lung developmental program and modify the pace of normal lung aging by reducing the resilience of the lungs to future GxExT interactions. Accordingly, lifelong GxExT interactions determine the individual trajectome and, eventually, the occurrence of COPD and associated multimorbidity. PredictCOPD aims to identify the interactions and mechanisms that determine which individuals will develop COPD and multimorbidty at some point of their life. The specific aims are: 1) to identify the lifelong environmental and host risk factors associated with the trajectome, COPD and multimorbidity, 2) to use a novel liquid biopsy method to identify biological factors driving the trajectome, COPD and multimorbidity; 3) to identify clinically relevant preventive and/or early therapeutic targets integrating the results from aims 1 and 2 with novel analytical approaches and 4) to validate findings both in vitro and in other available cohorts. The project will leverage from several available population and COPD patient studies with available clinical data and biological samples. The results of PredictCOPD have the potential to: 1) promote healthy ageing by preventing and eventually eradicate COPD and associated multimorbidity; and, 2) change COPD treatment from palliative to causal.

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