PredictCOPD
Financiado
Understanding the host environmental interactions across the lifespan determinin...
Understanding the host environmental interactions across the lifespan determining lung function trajectories and COPD
Chronic Obstructive Pulmonary Disease (COPD) has been traditionally understood as a self-inflicted disease caused by tobacco smoking occurring in old individuals. Over the past few years, however, our group and others have propose...
Chronic Obstructive Pulmonary Disease (COPD) has been traditionally understood as a self-inflicted disease caused by tobacco smoking occurring in old individuals. Over the past few years, however, our group and others have proposed that the pathogenesis of COPD goes beyond smoking, and that there is a range of lung function trajectories through life (trajectome); some of them have roots in early life and can lead to COPD, cardiovascular and metabolic morbidity as well as premature death, while others are associated with healthy ageing. Here I propose that, detrimental gene (G) and environment (E) interactions occurring early in life (T) constitute a ‘first injury hit’ that alters the normal lung developmental program and modify the pace of normal lung aging by reducing the resilience of the lungs to future GxExT interactions. Accordingly, lifelong GxExT interactions determine the individual trajectome and, eventually, the occurrence of COPD and associated multimorbidity. PredictCOPD aims to identify the interactions and mechanisms that determine which individuals will develop COPD and multimorbidty at some point of their life.
The specific aims are: 1) to identify the lifelong environmental and host risk factors associated with the trajectome, COPD and multimorbidity, 2) to use a novel liquid biopsy method to identify biological factors driving the trajectome, COPD and multimorbidity; 3) to identify clinically relevant preventive and/or early therapeutic targets integrating the results from aims 1 and 2 with novel analytical approaches and 4) to validate findings both in vitro and in other available cohorts.
The project will leverage from several available population and COPD patient studies with available clinical data and biological samples. The results of PredictCOPD have the potential to: 1) promote healthy ageing by preventing and eventually eradicate COPD and associated multimorbidity; and, 2) change COPD treatment from palliative to causal.
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Duración del proyecto: 63 meses
Fecha Inicio: 2022-08-02
Fecha Fin: 2027-11-30
Fecha Fin: 2027-11-30
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-02
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2021-COG:
ERC CONSOLIDATOR GRANTS
Cerrada
hace 3 años
Presupuesto
El presupuesto total del proyecto asciende a
2M€
Líder del proyecto
UNIVERSIDAD DE BARCELONA
No se ha especificado una descripción o un objeto social para esta compañía.
Total investigadores
328
Total investigadores
328
253.75K€ |
Participante