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PID2020-115189GB-I00

Financiado

ENTENDIENDO EL IMPACTO DE LA UTILIZACION DE DOSIS SERIADAS DE PROTEINAS IN VIVO...

ENTENDIENDO EL IMPACTO DE LA UTILIZACION DE DOSIS SERIADAS DE PROTEINAS IN VIVO SOBRE LA PROLONGACION DE LA ESPERANZA DE VIDA AGING INVOLVES A SET OF PHYSICAL DECLINES IN TISSUES, CELLS, AND MOLECULES, ALL OF WHICH EXHIBIT FUNCTIONAL CHANGES THAT TOGETHER INCREASE THE RISK OF DEATH, THESE DECLINES CAN BE SLOWED IN THE LABORATORY BY DIETARY, PHARMACEUTICA... ver más

01/01/2020

FUNDACIO PRIVADA C...

182K€

Presupuesto del proyecto: 182K€

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FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2020-01-01 No tenemos la información de la convocatoria

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Líder del proyecto

FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 182K€

Descripción del proyecto AGING INVOLVES A SET OF PHYSICAL DECLINES IN TISSUES, CELLS, AND MOLECULES, ALL OF WHICH EXHIBIT FUNCTIONAL CHANGES THAT TOGETHER INCREASE THE RISK OF DEATH, THESE DECLINES CAN BE SLOWED IN THE LABORATORY BY DIETARY, PHARMACEUTICAL, AND GENETIC INTERVENTIONS THAT EXTEND BOTH YOUTHFUL VIGOUR AND LIFESPAN, THE SUCCESSFUL EXTENSION OF LIFESPAN IN LABORATORY MODELS HAS MOTIVATED AN EXPLOSION OF TRANSLATIONAL AND CLINICAL EFFORTS TO INTERVENE IN HUMAN AGEING, A MODEST DELAY IN AGE-ASSOCIATED DECLINES IN HEALTH WOULD YIELD DRAMATIC ECONOMIC AND SOCIAL BENEFITS, INCREASING THE PRODUCTIVITY AND QUALITY OF LIFE OF OLDER CITIZENS WHILE REDUCING THE COSTS OF NATIONAL HEALTH CARE SYSTEMS,IN INVERTEBRATES, SEVERAL METHODS EXIST TO EXTEND LIFESPAN BY 200% OR MORE, UNFORTUNATELY, SINGLE INTERVENTIONS IN MOUSE MODELS TEND TO YIELD MORE MODERATE EFFECTS, AND DESPITE HUMANS SHARING EVOLUTIONARY-CONSERVED MECHANISMS OF AGING, IT REMAINS SPECULATIVE TO WHAT EXTENT HUMAN LIFESPAN CAN BE EXTENDED, THIS LACK OF CLARITY HAS ITS ORIGINS IN OUR POOR QUANTITATIVE UNDERSTANDING OF THE DOSE-DEPENDENT RELATIONSHIPS AMONG AGING MECHANISMS IN ANY ORGANISM, MOST FOUNDATIONAL WORK CONSIDERING THE MOLECULAR GENETICS OF AGING IN C, ELEGANS WAS BASED ON THE STUDY OF MUTANT ALLELES AND RNA-INTERFERENCE CONSTRUCTS, WHICH PROVIDE ONLY RUDIMENTARY CONTROL OVER THE MAGNITUDE OF INTERVENTIONS, TO PREDICT THE DOSE-DEPENDENT EFFECTS OF INTERVENTIONS IN HUMAN AGEING, WE MUST FIRST UNDERSTAND THE DOSE-DEPENDENT EFFECTS OF INTERVENTIONS IN MODEL SYSTEMS,IN THE PREVIOUS PLAN ESTATAL GRANT CYCLE, MY GROUP DEVELOPED A TRANSCRIPTOMIC APPROACH TO EFFICIENTLY COLLECT COLLECT INDIVIDUALLY-RESOLVED TRANSCRIPTOMES IN LARGE POPULATIONS, APPLYING THIS METHOD TO STUDY LIFESPAN-EXTENDING INTERVENTIONS, WE IDENTIFIED A SET OF ELEVEN, EVOLUTIONARY-CONSERVED DOWNSTREAM TARGETS SHARED BETWEEN THREE LIFESPAN EXTENDING INTERVENTIONS: DISRUPTION OF THE INSULIN/IGF SIGNALLING PATHWAY, CHANGES IN BODY TEMPERATURE, AND CHANGES IN DIET, BUILDING ON THESE RESULTS, WE WILL CHARACTERIZE THESE CANDIDATES TO UNDERSTAND THEIR CAUSAL ROLE IN LIFESPAN EXTENSION, TO UNDERSTAND THESE GENES EFFECT ON AGE-ASSOCIATED GENE REGULATORY CHANGES AND LIFESPAN, WE COMBINE OUR TRANSCRIPTOMIC METHOD WITH THE AUXIN-INDUCIBLE DEGRON SYSTEM TO STUDY THE DOSE-DEPENDENT RELATIONSHIP BETWEEN TRANSCRIPTS, GENE REULATORY NETWORKS, AND LIFESPAN, WE WILL USE THE AUXIN SYSTEM TO PRODUCE AN IN VIVO DOSAGE SERIES OF PROTEIN ACTIVITY OF TARGET GENES TO IDENTIFY DOSE-RESPONSIVE ELEMENTS OF THE TRANSCRIPTOME, IN THIS WAY, WE DEVELOP A SET OF METHODS AND A LIST OF CANDIDATE PROTEINS THAT CAN BE APPLIED ACROSS DIVERSE CONTEXTS, INCLUDING THE FUTURE ANALYSIS OF HUMAN DATA, ENVEJECIMIENTO\TRANSCRIPTOMICA\SEÑALIZACION DE INSULINA/IGF

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