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Engineering biological timers and their applications
Living cells are endowed with encoded programs that allow them to execute vital tasks and respond to relevant stimuli. The use of analogous (synthetic) programs has an enormous potential, yet we are highly limited in our ability t... Living cells are endowed with encoded programs that allow them to execute vital tasks and respond to relevant stimuli. The use of analogous (synthetic) programs has an enormous potential, yet we are highly limited in our ability to program cellular actions over time. We rely on precisely-timed human intervention or on molecular oscillators that control repetitive processes, but we are still unable to program cells to autonomously execute custom actions at desired times. I now intend to make a big leap toward this goal by producing control systems (molecular timers) and associated, ready-to-use applications, for the precise and self-sufficient control of cellular actions over time. Specifically, I will engineer timer gene circuits into E. coli that compute time and perform desired actions at specified moments. Timers will be highly programmable, re-usable, and scalable, and I will exploit their potential by using them for different applications, including bioproduction and biosensing. In sum, I will develop the highly-needed, ground-breaking ability to measure and program time in cells. My results will unleash a myriad of new possibilities, both fundamental and applied. ver más
30/06/2029
UPF
2M€
Duración del proyecto: 67 meses Fecha Inicio: 2023-11-21
Fecha Fin: 2029-06-30

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-11-21
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2023-STG: ERC STARTING GRANTS
Cerrada hace 2 años
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
UNIVERSITAT POMPEU FABRA No se ha especificado una descripción o un objeto social para esta compañía.
Total investigadores 321