Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

EndoRPHIm

Financiado

Cerrado

Endogenous Retroelements As Transcriptional Parasites And Modulators Of Host Imm...

Endogenous Retroelements As Transcriptional Parasites And Modulators Of Host Immunity Almost half of our genome is occupied by ancient viral sequences that can be mobilized under certain conditions and either jump or copy themselves from one location to another. A group of these mobile genetic elements is called en... ver más

31/05/2028

UKB

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITATSKLINIKUM BONN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-06-01

ERC-2021-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

UKB

Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

ECoToL Deciphering the molecular mechanism of Eleos, a conserved im... 212K€ Cerrado

RETROELEMENTS Diversity Generating Retroelements Understanding a New Cla... 100K€ Cerrado

G-EDIT Mechanisms of RNA guided genome editing in eukaryotes 2M€ Cerrado

EVOLINE Mobile elements shuffling the regulome in development and d... 265K€ Cerrado

PGC2018-097573-A-I00 EPITRANSCRIPTOMA, LNCRNAS Y VARIANTES DE RIESGO: IMPLICACION... 218K€ Cerrado

PID2020-113207GB-I00 TRANSCRIPTASAS INVERSAS BACTERIANAS Y SUS SISTEMAS ASOCIADOS... 254K€ Cerrado

Duración del proyecto: 59 meses Fecha Inicio: 2023-06-01
Fecha Fin: 2028-05-31

Líder del proyecto

UNIVERSITATSKLINIKUM BONN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Almost half of our genome is occupied by ancient viral sequences that can be mobilized under certain conditions and either jump or copy themselves from one location to another. A group of these mobile genetic elements is called endogenous retroelements. Mobilization of retroelements like LINE1 has been shown to cause cancer via insertional mutagenesis. In recent years LINE1 activation has also been associated with the development of inflammatory diseases and inflammation-driven ageing. This means, we collected substantial evidence that half of our genome can potentially make us sick. Nevertheless, we keep replicating these sequences with every cell division at great energetic cost, suggesting that keeping them provides an evolutionary advantage. In my project I will investigate if sporadic retroelement transcription in healthy cells serves a physiological role in priming the immune system through the constant sensing of retroelement-derived nucleic acids by intracellular nucleic acid sensors. My team and I will investigate how retroelement transcription is regulated in response daily life stresses like virus infections or DNA damage. I propose that instead of regulating transcription themselves, retroelements are largely regulated by canonical gene expression. In mouse models we will investigate how retroelements are sensed by the innate immune system and if this has functional consequences for establishing protective and pathologic immunity. Furthermore, we will investigate the exact molecular mechanism, by which retroelement-derived single stranded cDNA activates the innate immune system, which is currently not understood. Our project involves the development of a new deep sequencing workflow for identification of the genomic origin of retroelement transcripts and a new mouse model to study endogenous LINE1 elements in vivo. I believe that my project can fundamentally change our view on the role of endogenous retroelements as modulators of host immunity.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores