Innovating Works

ECoToL

Financiado
Deciphering the molecular mechanism of Eleos, a conserved immune system across t...
Deciphering the molecular mechanism of Eleos, a conserved immune system across the tree of life Sensing viral infections and mounting a response is crucial for all domains of life. Many immune mechanisms in higher eukaryotes were thought to be evolutionary innovations, but recent research reveals that some components of the... Sensing viral infections and mounting a response is crucial for all domains of life. Many immune mechanisms in higher eukaryotes were thought to be evolutionary innovations, but recent research reveals that some components of the innate immune system have evolved from bacterial genes. Eleos, a novel anti-viral system in prokaryotes, shares similarities with eukaryotic GIMAPs (GTPase immunity-associated proteins), yet their evolutionary history and anti-viral mechanisms remain unknown. ECoToL's objectives are threefold: 1. Identify Eleos systems, study their architecture, and determine their distribution in bacteria. 2. Explore the molecular mechanism by which bacterial Eleos confers resistance against phages. 3. Investigate when and how Eleos was acquired in eukaryotes, assess its distribution, and examine the conservation of the mechanism in eukaryotes. We will analyze large genome datasets to trace Eleos system evolution across different life domains. Additionally, we will identify phages Eleos defends against and the mechanisms by which phages evade this defense. Biochemical, biophysical, and structural biology methods will illuminate the molecular mechanisms in bacterial Eleos. Further genomic analysis and experimental methods will answer whether this mechanism is conserved in higher eukaryotes. ECoToL is a multidisciplinary project pioneering comparative immunology between prokaryotes and eukaryotes. This innovative concept aims to enhance our understanding of immune systems, which is critical for staying ahead of viral threats, improving viral infection treatments, reducing viral resistance, and enhancing global health security. ver más
15/08/2026
IP
212K€
Perfil tecnológico estimado
Duración del proyecto: 28 meses Fecha Inicio: 2024-04-10
Fecha Fin: 2026-08-15

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-10
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023
Cerrada hace 1 año
Presupuesto El presupuesto total del proyecto asciende a 212K€
Líder del proyecto
INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5